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SUMMARY:Genome Architecture Mapping (GAM): an Orthogonal Approach to Map C
 hromatin Contacts Genome-Wide
DTSTART:20170116T110000
DTSTAMP:20260510T084150Z
UID:9bc19420b3214e0c12316ae2bd1c74ff46bcc27b3780ebdf1ed6c942
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ana Pombo\, Humboldt University\, Berlin (D)\nBIOENGINEE
 RING SEMINAR\n\nAbstract:\nThe organization of the genome in the nucleus a
 nd the interactions of genes with their regulatory elements are key featur
 es of transcriptional control and their disruption causes disease. Technol
 ogies based on chromosome conformation capture (3C) have profoundly expand
 ed our understanding of the role of genome architecture in gene regulation
 . We introduce Genome Architecture Mapping (GAM)\, an orthogonal genome-wi
 de method for measuring three-dimensional chromatin topology\, which requi
 res small cell numbers and can be applied directly in tissue. Exploration 
 of the most prominent chromatin contacts detected using GAM in the nucleus
  of mouse ES cells identifies the most specific chromatin contacts between
  active genes and enhancers across very large genomic distances. Our resul
 ts highlight a previously inaccessible complexity in genome architecture a
 nd a major role for contacts related with gene expression in the structura
 l organisation of the genome in mammalian nuclei.\n\nBio:\nOriginally from
  Lisbon\, Portugal\nBSc: University of Lisbon\, Lisbon\, Portugal\nDPhil
 : University of Oxford\, UK
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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