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SUMMARY:Serotonin as a new therapeutic target for diabetes mellitus and ob
 esity
DTSTART:20170427T103000
DTEND:20170427T113000
DTSTAMP:20260503T123436Z
UID:172b73b4c2e32fc7229b60982b28eb1a2a21bf0a12596d157f3206d1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Chang Myung OH\, Department of Internal Medicine\, CHA Bundang
  Medical Center\, School of Medicine CHA University\, Seongnam\, Korea\nSE
 MINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA
 )\n\nAbstract:\nSerotonin (5-hydroxytryptamine or 5-HT) is a monoamine tha
 t has various functions in both neuronal and non-neuronal systems. Recent 
 studies revealed that peripheral 5-HT plays an important role in metabolic
  regulation in peripheral tissues. Inhibition of 5-HT synthesis reduced th
 e weight gain and improved the metabolic dysfunction in a diet-induced obe
 sity mouse model. Pharmacological inhibition of 5-HT synthesis suppressed 
 the lipogenesis in epididymal white adipose tissue (WAT)\, induced beige a
 dipogenesis in inguinal WAT and activated the adaptive thermogenesis in br
 own adipose tissue. Mice genetically depleted adipocyte serotonin exhibite
 d similar phenotypes\, suggesting the localized effects of 5-HT on adipose
  tissues. These results support the clinical significance of the periphera
 l serotonergic system as a therapeutic target for obesity and diabetes.\n\
 nIMPORTANT NOTICE: \nAll external participants have to pass through SV Rec
 eption/Welcome Desk to be able to access room AI 1153.\nContact person to 
 call at arrival at SV Reception Desk:\n   Johan Auwerx 30951 / Administr
 ative Assistant: 39522.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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