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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Mitochondrial Quality Control
DTSTART:20170216T103000
DTEND:20170216T113000
DTSTAMP:20260407T103616Z
UID:3e280e6031efd7d34e6c96c56a59ce52486230b065969b05fc52c69e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ziheng CHEN\, Group of Apoptosis and Cancer Biology\, Institut
 e of Zoology\, Chinese Academy of Sciences\, Beijing\, China\nSEMINAR of t
 he LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)\n\nTo pr
 otect against mitochondrial damage from environment including oxidative st
 ress\, cell have developed well-coordinated mechanisms to monitor mitochon
 drial health. These Mitochondrial Quality Control (MQC) mechanisms include
  mitochondrial dynamic and mitophagy. Here\, we uncovered that the mitocho
 ndrial E3 ligase MARCH5 plays a role in regulating hypoxia-induced mitopha
 gy by ubiquitylating and degrading mitophagy receptor FUNDC1\, revealing a
  novel feedback regulatory mechanism to control the protein levels of a mi
 tochondrial receptor to fine-tune MQC. As a part of collaborative research
  project\, we have also revealed an unconventional function of non-degrada
 tive ubiquitination of Mfns in promoting mitochondrial fusion.\n\nIMPORTAN
 T: \nAll external participants have to pass through  SV Reception/Welcome
  Desk to be able to access to AI 1153.\n\nContact person to call at arriva
 l at SV Reception Desk: Johan Auwerx 30951 /Administrative Assistant: 3952
 2.  
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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