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SUMMARY:Physical Systems Biology of Microbes
DTSTART:20170201T140000
DTEND:20170201T150000
DTSTAMP:20260503T095436Z
UID:fb8b403f97b30757822d48fecc0404a480058462ababb612422dfde5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Enrique Rojas\, Stanford University\nAbstract:\nA central 
 goal of systems biology is to elucidate the pathways by which information 
 is communicated within cells in order to control subcellular processes.  
 While research often focuses on genetic and enzymatic pathways\, I will hi
 ghlight four novel paradigms by which microbes use physical factors\, incl
 uding mechanical forces and electric fields\, as signals to control cell g
 rowth\, division\, and survival.  First\, I will describe how Gram-negati
 ve bacteria survive and grow robustly during mechanical perturbation by be
 aring mechanical forces in their outer membrane and by “storing” cell 
 envelope synthesis during perturbation.  Next\, I will explain how the pa
 thogenic bacterium Staphylococcus aureus harnesses internal hydrostatic 
 pressure to drive sub-millisecond cell division.  Finally\, I will detail
  how Gram-positive bacteria use membrane tension and membrane depolarizati
 on as signals to ensure balanced synthesis of the plasma membrane and the 
 cell wall.  I will conclude by outlining an exciting roadmap for the futu
 re study of physical systems biology of microbes\, including several quest
 ions that follow directly from my present research.
LOCATION:PH H3 31 https://plan.epfl.ch/?room==PH%20H3%2031
STATUS:CONFIRMED
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