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SUMMARY:The physical epigenome: Quantitative approaches to characterize ep
 igenetic systems
DTSTART:20170202T080000
DTEND:20170202T090000
DTSTAMP:20260509T175359Z
UID:0a4b0c6ec5b4e567f7c30f1e255380dcbe79d722875fbc23a7df0650
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Courtney Hodges\, Stanford University\nAbstract:\nEpigene
 tic regulatory mechanisms are critical for multicellular development and n
 ormal function. Indeed\, the deregulation of these systems is a hallmark o
 f cancer and other disorders. However\, many essential regulatory events a
 rise through short-lived interactions\, which are difficult to characteriz
 e with conventional epigenetic approaches. To overcome this limitation\, I
  have used novel physical and quantitative techniques to characterize epig
 enetic processes. In this talk\, I will briefly describe three examples: (
 1) the use of single-molecule manipulation to reveal the dynamic barrier p
 osed to RNA polymerase by nucleosomes\; (2) integration of stochastic simu
 lations with experiment to characterize heterochromatin formation and stab
 ility\; and (3) applying quantitative epigenomics to reveal the mechanisms
  of ATP-dependent chromatin remodeling disrupted in cancer. These studies 
 illuminate the physical basis for chromatin regulation\, from detailed mec
 hanisms of single molecules to global effects spanning the genome. My futu
 re research will integrate new "omic"-based strategies with single-molecul
 e biophysical approaches\, to reveal the quantitative principles governing
  epigenetic systems.
LOCATION:PH H3 31 https://plan.epfl.ch/?room==PH%20H3%2031
STATUS:CONFIRMED
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