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SUMMARY:Biophysics at the truly single-molecule level
DTSTART:20170202T163000
DTEND:20170202T173000
DTSTAMP:20260413T212256Z
UID:59961f36fce8e0cddbb95ba59ffdcf160d29d9dc899c8b76013d6bf6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Jean-Nicolas Longchamp\, University of Zurich\nAbstract:\
 nImaging single proteins and protein complexes at atomic resolution has be
 en a long-standing dream for advancing biophysics and structural biology a
 nd with this various fields in natural science. After a short introduction
  in the field\, I will show how by means of preparative mass-spectrometry\
 , for the specific selection and gentle deposition of individual proteins 
 onto ultraclean freestanding graphene\, and low-energy electron holography
  for the non-destructive imaging\, the first images of single proteins at 
 sub-nanometer resolution were recently obtained. I will then focus on the 
 future perspectives for this novel technology\, especially the fundamental
  biological questions that could be addressed as well as the remaining cha
 llenges to attain atomic resolution and 3D-imaging. Finally\, I will show 
 that low-energy electron holography has the potential for microseconds tim
 e-resolved experiments as for instance imaging proteins conformational cha
 nges in a pump-probe like experimental scheme. 
LOCATION:PH H3 31 https://plan.epfl.ch/?room==PH%20H3%2031
STATUS:CONFIRMED
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