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SUMMARY:BMI Seminar // Molecular architecture of synapses in situ by cryo-
 electron tomography
DTSTART:20170531T121500
DTEND:20170531T131500
DTSTAMP:20260501T180058Z
UID:582ed85e526a41e2d7960d8351df179bc6eaac50ea74b941ee46f9fd
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ashraf Al-Amoudi\, German Center for Neurodegenerative Disease
 s\, Bonn\, Germany  \nUnderstanding synaptic structure\, function\, conne
 ctivity and plasticity is fundamental to understanding how the brain works
 . Synaptic plasticity is fundamental for learning and memory formation whe
 re neurons are able to shape their length\, structure and distribution of 
 synapses thus accommodating local synaptic activity. Under pathological co
 nditions such as Alzheimer’s disease\, uncontrolled large-scale loss of 
 synapses triggers local neural degeneration. We use a variety of advanced
  biophysical techniques to study the structure\, the function and plastici
 ty of synapses. These include sample cryopreservation\, and cryo- electron
  microscopy and tomography of specimens from mouse models\, cultured cell
 s or primary cell lines and correlative light and electron microscopy and 
 tomography. In my talk\, I will show the detailed analysis of the three-di
 mensional molecular architecture of presynaptic active zones of specific t
 ype of synapses and how they function. This study will open possibilities\
 , using these advanced techniques\, to investigate the synaptic structural
  plasticity in normal aging as well as in neural disorder and age-related 
 dementia (e.g. Alzheimer model disease) and to understand the molecular me
 chanism of neurodegenerative diseases.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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