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SUMMARY:Glycosphingolipids and Metabolic Syndrome
DTSTART:20120307T150000
DTEND:20120307T160000
DTSTAMP:20260916T050015Z
UID:1222bf34ee7db6a1a2285fe28df6f3276f02d8681339f504b3f6c8b1
CATEGORIES:Conferences - Seminars
DESCRIPTION:\n\n\n\n\n\n\n\n\n\nDr. Carmen ARGMANN\, Department of Medical
  Biochemistry\, Academic Medical Center\, Amsterdam.\n\n\n\n\n\n\n\n\n\n\n
 \n\n\n	Insulin resistance is associated with the lipid oversupply in obesi
 ty and as such has motivated the search for lipid mediators that can inter
 fere with insulin signaling and glucose homeostasis. One class of lipids e
 levated in tissues of obese humans and rodents include the (glyco)sphingol
 ipids suggesting these bioactive lipids may play a crucial role in insulin
  resistance.  We recently demonstrated that in animal models pharmacologi
 cal reduction of glycosphingolipid biosynthesis ameliorates insulin resist
 ance and prevents some manifestations of metabolic syndrome thereby suppor
 ting this concept. Since the critical (glyco)sphingolipid entities and the
 ir mechanisms are still uncertain\, a systems biology approach is needed t
 o complement classic biochemistry in understanding the role of glycosphing
 olipids in insulin resistance.\n
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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