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SUMMARY:mTORC1 signaling orchestrates bimodal control of food intake by hy
 pothalamic POMC neurons
DTSTART:20170317T113000
DTEND:20170317T123000
DTSTAMP:20260915T231748Z
UID:a0f69e1f341508e33d196397d7e025968b7b2f1d633d7b149b37bc3f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Daniela Cota  Group "Energy Balance and Obesity"\, INSERM 
 U1215\, Université de Bordeaux\, NeuroCentre Magendie\, Bordeaux\, France
 \n\nFood intake is a highly complex behavior controlled by a series of neu
 ral circuits containing specialized neuronal cell types. Proopiomelanocort
 in (POMC)-expressing neurons of the hypothalamic arcuate nucleus play a ma
 jor role in the regulation of energy balance and are therapeutic target fo
 r the treatment of obesity. POMC neurons are classically considered as key
  drivers of the cessation of feeding. By using single-cell RNA analysis\, 
 pharmacology\, electrophysiology\, chemo- and optogenetics we now demonstr
 ate that POMC neurons form different subpopulations able to produce both e
 xcitatory and inhibitory neurotransmitters. Our study therefore demonstrat
 es that GABAergic and glutamatergic POMC neurons participate to the regula
 tion of feeding behavior and that their function is under the control of t
 he mechanistic target of rapamycin (mTOR) pathway and the cannabinoid type
  1 (CB1) receptor signaling\, two molecular main players of the regulation
  of neuronal activity and function.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CANCELLED
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