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SUMMARY:The chemical characterization of the brain: from new measurement t
 ools to new neurochemical insights
DTSTART:20170323T170000
DTEND:20170323T180000
DTSTAMP:20260921T232812Z
UID:9980a9136cf8f9bef065e2dbbe0f4d2d8ee095fd935b07d5bf4eb198
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jonathan V. Sweedler\, University of Illinois\, USA\nIn the po
 stgenomic era\, one expects the suite of chemical players in a brain regio
 n to be known and their functions uncovered. However\, many cell-to-cell s
 ignaling molecules remain poorly characterized and for those that are know
 n\, their localization and dynamics are oftentimes unknown. A suite of sma
 ll-scale measurement approaches are described that allow the investigation
  of individual neurons and small brain regions\; these approaches include 
 capillary scale separations\, direct mass spectrometric-based profiling an
 d mass spectrometry imaging. Several applications of single cell microanal
 ysis are highlighted including the discovery of unusual metabolites to cha
 racterizing the neuropeptides in single cells. Single cell assays allow di
 fferences in the metabolome and peptidome from supposedly homogeneous popu
 lations of cells to be explored. As a further example\, a unique matrix as
 sisted laser desorption / ionization time of flight mass spectrometry appr
 oach is described that probes thousands of endocrine cells for their pepti
 de content. Current technology efforts involve extending the depth of meta
 bolome coverage and adapting our approaches to high throughput single cell
  assays. By obtaining information from tens of thousands of individual cel
 ls\, rare cells are found and subtle differences in cell populations are m
 easured. Imaging mass spectrometry and dynamic sampling of the extracellul
 ar environment also provide a functional context for the discovery of nove
 l cell to cell signaling molecules. Our overarching goal is to uncover the
  complex chemical mosaic of the brain and pinpoint key cellular players in
  a range of physiological and pathological processes.\n\n\n\n \n 
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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