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SUMMARY:Human Mtb-specific T-cell responses in blood and tissue
DTSTART:20111213T110000
DTSTAMP:20260924T071641Z
UID:ee415e8112d482f770aa074c6effc577ce79fe1e32383442265bff72
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Alexandre Harari\nT lymphocytes are thought to play an imp
 ortant role in the control of TB since Mtb reactivates when there is a dec
 rease in immune surveillance. The Mtb-specific T-cell response is a typica
 l Th1 response and the main function of these CD4 T cells is to produce cy
 tokines such as IFN-γ or TNF-α that contribute to the recruitment of mon
 ocytes and granulocytes and activate the anti-microbial activity of macrop
 hages. In some studies\, Th17 cells were shown to be involved in the early
  formation of protective immunity in the lung whereas other investigations
  indicated that Th17 cells were not associated to protection. Another open
  question is centered on the role of Mtb-specific CD8 T-cells. Indeed\, wo
 rk performed in mouse models of TB suggested a role of these cells in the 
 control of Mtb infection. Specifically\, secretion of perforin and granuly
 sin by Mtb-specific CD8 T cells was required to protect mice from Mtb infe
 ction. Other studies performed in humans reached the same conclusions. How
 ever\, the mechanisms underlying CD8 T-cell priming and recruitment remain
  to be clarified (e.g. what are the cell subsets allowing Mtb-derived epit
 ope presentation on MHC class I molecules). Finally\, most research in hum
 ans was performed in cells isolated from the blood and little is known reg
 arding the magnitude or the quality of Mtb-specific T-cells at the sites o
 f infection (e.g. in the lung for pulmonary TB\, which represents the most
  common type of TB disease). Recently a comprehensive investigation of Mtb
 -specific CD4 and CD8 T- cells using polychromatic flow cytometry in patie
 nts with latent Mtb infection or active TB disease was performed at the Se
 rvice of Immunology and Allergy from CHUV. In addition\, both Th1 and Th17
  T-cell subsets were analyzed in peripheral blood as well as in blonchoalv
 eolar lavages. Data from these investigations will be presented during the
  seminar.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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