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SUMMARY:Discovery of Bio-instructive Materials
DTSTART:20170314T121500
DTSTAMP:20260415T024340Z
UID:a25bf216a4f6e5744a1e91f0039f1c8c90e037e6b56c7a491fffb692
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Morgan Alexander\, University of Nottingham\, Nottingham
  (UK)\nBIOENGINEERING SEMINAR\n(sandwiches served)\n\nAbstract:\nThe range
  of biomaterials found in the clinic today are dominated by materials chos
 en on the basis of their availability and mechanical properties rather tha
 n positive interactions with surrounding cells and tissues. It would be de
 sirable to design our way forward from this situation to new biomaterials.
  Unfortunately our understanding of the bio-interface is poor\, with only 
 isolated cases where a good understanding of cell-material interactions ca
 n be cited\, and fewer still where material-tissue interactions are well c
 haracterised and understood. This paucity of information on the mechanism 
 of biomaterial interactions with the body acts as a roadblock to rational 
 design. Consequently we have taken a high throughput screening approach to
  discover new bio-instructive materials from large chemical libraries- thi
 s approach can be described as the engineering serendipitous discovery.[1]
  These new candidate biomaterials provide a starting point for development
  of new medical devices and provide opportunities to study their mechanism
  of action to provide new information to tackle the rational design roadbl
 ock.\n    A polymer micro array screening approach has been used to ide
 ntify bio-instructive materials in the discovery of polymers with applicat
 ion in expansion of pluripotent human embryonic stem cells and the identif
 ication of substrates on which to mature cardiomyocytes.[2\,3\,4] Other sc
 reening campaigns using macrophage differentiation have identified bio-ins
 tructive materials with pro- and anti-inflammatory characteristics with gr
 eat potential in modulating the human immune system in novel therapies and
  devices.[5] Materials resisting bacterial attachment and biofilm have als
 o been identified and will be presented\, with early data on the investiga
 tion of their mechanism of biofilm formation resistance.[6] Work to integr
 ate and expand this range of bio-instructive materials will be previewed\,
  including moves underway towards 3D screening.\n \n\n	Magennis\, E.P.\, 
 Hook\, A.L.\, Davies\, M.C.\, Alexander\, C.\, Williams\, P.\, and Alexand
 er\, M.R. Engineering serendipity: High-throughput discovery of materials 
 that resist bacterial attachment. Acta Biomaterialia 34\, 84 (2016).\n	Mei
 \, Y.\; Saha\, K.\; Bogatyrev\, S.R.\; Yang\, J.\; Hook\, A. L…Van Vliet
 \, K.J.\; Davies\, M.C.\; Alexander\, M.R.\; Langer\, R.\; Jaenisch\, R.\;
  Anderson\, D.G. Combinatorial development of biomaterials for clonal grow
 th of human pluripotent stem cells. Nature Materials 2010\, 9 (9)\, 768-77
 8.\n	Celiz\, A.D.\; Smith\, J.G. W.\; Patel\, A.K.\; Hook\, A.L.\; Rajamoh
 an\, D.\; George\, V.T.\; Flatt\, L.\; Patel\, M.J.\; … Langer\, R.\; An
 derson\, D. G.\; Allen\, N.D.\; Hay\, D. C.\; Winkler\, D.A.\; Barrett\, D
 .A.\; Davies\, M.C.\; Young\, L.E.\; Denning\, C.\; Alexander\, M.R. Disco
 very of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Mult
 ilineage Differentiation. Advanced Materials 2015\, 27 (27)\, 4006-4012.\n
 	Patel\, A.K.\, Celiz\, A.D.\, Rajamohan\, D.\, Anderson\, D.G.\, Langer\,
  R.\, Davies\, M.C.\, Alexander\, M.R.\, and Denning\, C. A defined synthe
 tic substrate for serum-free culture of human stem cell derived cardiomyoc
 ytes with improved functional maturity identified using combinatorial mate
 rials microarrays. Biomaterials 61\, 257 (2015).\n	Rostam et al. in prepar
 ation.\n	Hook\, A\, Chang\, C\, Yang\, Luckett\, J\, Cockayne\, A\, Atkins
 on\, S\, Mei\, Bayston\, R\, Irvine\, D\, Langer\, R\, Anderson\, D\, Will
 iams\, P\, Davies\, M\, and Alexander\, MR Erratum: Combinatorial discover
 y of polymers resistant to bacterial attachment Nature Biotechnology 30 86
 8 (2012).\n\n\nBio:\nMorgan Alexander is Professor of Biomedical Surfaces\
 , the Director of the EPSRC Programme Grant in Next Generation Biomaterial
 s Discovery\, a Royal Society-Wolfson Research Merit Award holder and a We
 llcome Trust Senior Investigator. He received his BSc in Materials (1988) 
 and his PhD from the same department at The University of Sheffield in 199
 2.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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