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SUMMARY:Mechanical Control of Tissue Morphogenesis
DTSTART:20170314T160000
DTEND:20170314T170000
DTSTAMP:20260407T020812Z
UID:66984a907f3a5abd1b65f99b94ec30cd1ed7a38d6fc9a8906d1a144e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Otger Campàs\, University of California\, Santa Barbara
 \, CA (USA)\nBIOENGINEERING SEMINAR\n(sandwiches served)\n\nAbstract:\nThe
  sculpting of tissues into their functional morphologies requires a tight 
 spatiotemporal control of their mechanics. While cell-generated mechanical
  forces power morphogenesis\, the resulting tissue movements depend on the
  local tissue mechanical properties\, such as its stiffness and viscosity\
 , which govern the system's response to the internally generated forces. D
 espite their relevance\, the role of mechanical forces and mechanical prop
 erties in development processes remains largely unknown\, mainly because o
 f a lack in methodologies enabling direct in vivo and in situ measurements
  of cell-generated forces and mechanical properties within developing 3D t
 issues and organs. In this talk\, I will present two novel microdroplet-ba
 sed techniques that we have recently developed to quantify local cellular 
 forces and mechanical properties within developing 3D tissues. Using zebra
 fish as model system\, I will show that cellular forces do not vary strong
 ly in space and time\, whereas spatiotemporal changes in supra-cellular (t
 issue level) forces and mechanical properties correlate with morphogenetic
  events and spatial variations in cellular movements. These results indica
 te that spatiotemporal changes in tissue mechanical properties (stiffness\
 , fluidity\, etc.)\, rather than just cellular forces\, regulate the sculp
 ting of embryonic tissues.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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