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SUMMARY:BMI Seminar // The developing Huntington’s disease brain
DTSTART:20170412T121500
DTEND:20170412T131500
DTSTAMP:20260413T205115Z
UID:dd432b63d1b5ab4f9cfe82280308d806759c6c2cf7b87f43882c0c26
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sandrine Humbert\, Grenoble Institute of Neurosciences\, GIN -
  Inserm U1216\, Grenoble Alpes University\, Grenoble\, France\nThe bulk of
  interest in the huntingtin protein has centered on the fact that\, when m
 utated\, huntingtin causes Huntington’s disease (HD)\, a devastating neu
 rodegenerative disorder. The mutation causing HD is an abnormal polyglutam
 ine stretch in huntingtin. Given the adult onset and dysfunction and death
  of adult neurons characterizing HD\, most studies have focused on the tox
 ic effects elicited by mutant huntingtin in post-mitotic neurons. However\
 , the protein is ubiquitous and expressed in the developing embryo where i
 t plays an essential role as revealed by the early embryonic lethality at 
 day 7.5 of the complete knockout of the huntingtin gene in mouse. Anyway\,
  the roles of the wild-type protein during development have been overlooke
 d. I will discuss how huntingtin regulates several steps of mouse embryoni
 c corticogenesis. I will also show the consequences of the presence of an 
 abnormal polyglutamine expansion in huntingtin during cortical neurogenesi
 s and consider the viewing of HD as a developmental disorder.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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