BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Organs on a Chip: the Future of Precision Medicine?
DTSTART:20170321T110000
DTSTAMP:20260428T004201Z
UID:d50185c139b15e15f7c7ef24fb6d0c2d8571b108bba62673cd0876b2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Kevin E. Healy\, University of California\, Berkeley\, C
 A (USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING\n\nAbstract:\nDru
 g discovery and development are hampered by high failure rates attributed 
 to the reliance on non-human animal models employed during safety and effi
 cacy testing that poorly recapitulate human disease states. With the disco
 very of human induced pluripotent stem cells (hiPSCs)\, bioengineers can n
 ow develop in vitro disease specific tissue models to be used for high con
 tent drug screening and patient-specific medicine. Combining the genetic b
 ackground of human cells with appropriate biophysical tissue architecture 
 and “tissue-like” drug gradients can recapitulate a minimal human orga
 noid sufficiently to allow accurate prediction of the toxicity of drugs. T
 his presentation will discuss our progress in developing integrated in vit
 ro models of human cardiac and liver tissue based on populations of normal
  and patient specific hiPSCs differentiated into cardiomyocytes\, hepatocy
 tes\, or supporting cells. The benefits of our approach include: 1) robust
  microengineering platforms that control microtissue organization and func
 tion\; 2) precise delivery of molecules (e.g.\, drugs) in a computationall
 y predictable manner\; 3) ability to model human disease\; and\, 4) cost e
 fficient and high content characterization of an integrated multi-organ dr
 ug response.\n\nBio:\nKevin Healy received his Ph.D. at the University of 
 Pennsylvania in Bioengineering in 1990. His research interests are biomate
 rials and tissue engineering. The design and synthesis of biomimetic mater
 ials that actively direct the behavior of mammalian cells to facilitate re
 generation of tissue and organs\, and the design and synthesis of material
 s that circumvent their passive behavior in complex mammalian cells is the
  focus of the work conducted at Berkeley.\nHe holds the Jan Fandrianto and
  Selfia Halim Distinguished Professorship in Engineering in the Department
 s of Bioengineering and Materials Science & Engineering at UC Berkeley.\n
  
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR