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SUMMARY:BMI Seminar //  Multiple system atrophy: the oligodendroglial alph
 a-synucleinopathy
DTSTART:20170614T121500
DTEND:20170614T131500
DTSTAMP:20260408T025846Z
UID:8c0e00f0ce28ec5dfede1a198ff17f149d40bb5ce873141c07a92986
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nadia Stefanova\, Department of Neurology\, Division of Neurob
 iology\, Innsbruck Medical University\, Innsbruck\, Austria\nMultiple syst
 em atrophy (MSA) is a rare devastating neurodegenerative disorder commonly
  showing clinical overlaps with Parkinson’s disease (PD) and therefore o
 ften misdiagnosed in the daily praxis. MSA is characterized by ectopic fil
 amentous alpha-synuclein accumulation in oligodendrocytes (glial cytoplasm
 ic inclusions\, GCIs) in contrast to the classical Lewy body pathology in 
 neurons of PD and Dementia with Lewy bodies. Currently\, the pathogenic me
 chanisms of the disease are unclear. We are interested to develop pre-clin
 ical models of the disease that replicate the human pathology and natural 
 history of MSA and give us the possibility to get insights into the early 
 stages of the disease process. Finally\, we apply these models for target 
 validation and pre-clinical therapeutic screening with strong translation 
 input for clinical trials targeting alpha-synucleinopathy.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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