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PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:BMI Seminar  "To eat to not to eat: mitophagy in neurodegeneration
 "
DTSTART:20170510T121500
DTEND:20170510T131500
DTSTAMP:20260916T012407Z
UID:1cd137313cbae82d11e29bb3235bddfe8b8156214885674b580ccd61
CATEGORIES:Conferences - Seminars
DESCRIPTION:Elena Ziviani\, Department of Biology\, University of Padova\,
  Padova & Istituto IRCCS San Camillo\, Lido di Venezia\, Venezia\, Italy\n
 During mitophagy\, impaired in genetic Parkinson’s disease (PD)\, the ki
 nase PINK1 recruits the E3 ubiquitin ligase Parkin to damaged mitochondria
 . Increased Parkin levels correct PINK1 deficient Drosophila PD models\,
  suggesting that targeting the Parkin-opposing deubiquitination enzymes (D
 UBs) can yield the same result. A targeted RNA interference screening for
  DUBs antagonizing Parkin ubiquitination of its key mitochondrial target M
 itofusin identified six DUBs among which USP8 caught our attention. Bioche
 mical and functional analyses indicated that USP8 impinges on mitochondria
  dysfunction via Parkin and that genetic and pharmacological inhibition o
 f USP8 rescues a Drosophila model of PD.  Our data identify a novel th
 erapeutic target antagonizing pathologic symptoms in a model of PD
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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