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SUMMARY:Dissection of the SRF transcriptional network: from mechanisms to 
 cell behaviour.
DTSTART:20170330T160000
DTEND:20170330T170000
DTSTAMP:20260506T084440Z
UID:40cf47dbcb5dbfb3b7f64f66a221193417805633cb0c480263badc0b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Francesco GUALDRINI\, PhD\nSerum response factor (SRF) control
 s gene activation in response to changes in actin dynamics and mitogen-act
 ivated protein kinases.\nSRF has low intrinsic transcriptional activity an
 d requires the recruitment of one of two families of co-activators: the MR
 TFs (myocardin-related transcription factors) and the TCFs (ternary comple
 x factors). MRTFs are actin-binding proteins. The TCF family are specifica
 lly activated by MAPK signalling.\nAlthough much has been explored over th
 e past years\, little is known about the mechanisms these two pathways ado
 pt to control gene expression and the specific cohort of genes they activa
 te.\nDuring this seminar I will present the overall network architecture\,
  the strategy we adopted to identify target genes\, their wider functional
  significance and the mechanism involved in their activation.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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