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SUMMARY:Using Thermodynamics to Reveal the Mechanisms behind the Robust Ti
 cking\, Input Compensation and Entrainability of the Cyanobacterial Circad
 ian Clock
DTSTART:20170410T140000
DTSTAMP:20260928T203059Z
UID:7082b8acbd20a7a549037ca3a210ae9ef8d3ab0113d000bf910216b3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Joris Paijmans\, Ph.D.\, AMOLF\, Amsterdam (NL)\nBIOENGINEERIN
 G SEMINAR\n\nAbstract:\nThe circadian clock of the cyanobacterium S. elong
 atus\, called the Kai oscillator\, is one of the best studied and simplest
  found in biology. Remarkably\, the three clock proteins KaiA\, KaiB\, and
  KaiC\, together with ATP\, are sufficient to generate circadian phosphory
 lation of KaiC in a test tube. How this clock is driven thermodynamically 
 is still not well understood. In this talk I present our new mathematical 
 model of the in-vitro Kai system which simulates detailed dynamics of KaiC
  homohexamers as they traverse their phosphorylation cycle. Because all re
 actions uphold detailed balance\, we can precisely study how hydrolysis of
  ATP makes the clock tick. We then use this model to study another intrigu
 ing problem. All circadian clocks must be able to entrain to time-varying 
 signals to keep their oscillations in phase with the day-night rhythm. On 
 the other hand\, they must also exhibit input compensation: their period m
 ust remain about one day in different constant environments. The Kai syste
 m can be entrained by transient or oscillatory changes in the ATP fraction
 \, yet is insensitive to constant changes in this fraction. We show how\, 
 by a new mechanism at the level of individual hexamers\, the Kai system ca
 n meet these seemingly contradictory requirements.\n\nBio:\n2012–present
 \nPhD Researcher in Biophysics\nFOM Institute AMOLF\, Amsterdam\n\n2006 
 – 2011:\nBsc Natuur en Sterrenkunde\nMSc Theoretical Physics\nUniversity
  of Amsterdam
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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