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SUMMARY:“New Insights into mitochondrial Cox2 biogenesis”
DTSTART:20170426T103000
DTEND:20170426T113000
DTSTAMP:20260925T073451Z
UID:04ea3fa2b73c432078ec30c1e844393cc181be811115d5207c52c8ca
CATEGORIES:Conferences - Seminars
DESCRIPTION:Isotta Lorenzi Georg-August-University\, Göttingen\, Germany\
 nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LI
 MNA)\n\nAbstract:\nWithin mitochondria\, the biogenesis of the respiratory
  chain complexes (I to IV)\, is a highly coordinated process. Cox2 is a mi
 tochondrial-encoded central subunit of the complex IV. Using yeast as a mo
 del system\, we find that the ribosome receptor Mba1 forms a ribosomes-nas
 cent chain complex with ribosome translating Cox2 and the Cox2 chaperone C
 ox20. We propose a novel shuttling mechanism for newly synthesized Cox2 fr
 om the ribosome to maturing complex IV assembly intermediates. Complementa
 ry studies on human COX20 complexes have uncovered novel assembly factors 
 involved in COX2 biogenesis.\n\nIMPORTANT NOTICE: \nAll external participa
 nts have to pass through SV Reception/Welcome Desk to be able to access ro
 om AI 1153.\nContact person to call at arrival at SV Reception Desk:\n  
  Johan Auwerx 30951 / Administrative Assistant: 39522.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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