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SUMMARY:BMI Seminar // Metabolic regulation of adult neural stem cells
DTSTART:20170906T121500
DTEND:20170906T131500
DTSTAMP:20260916T043947Z
UID:73025b4db1b50bbbd2d92211d1a1bfd06c3711a8c42f440d23603365
CATEGORIES:Conferences - Seminars
DESCRIPTION:Marlen Knobloch\, Laboratory of Stem Cell Metabolism\, Departm
 ent of Physiology\, Faculty of Biology and Medicine\, UNIL\, Lausanne\, Sw
 itzerland\nNeural stem/progenitor cells (NSPCs) generate new neurons throu
 ghout life in distinct regions of the mammalian brain. Adult neurogenesis 
 is important for tissue homeostasis and physiological brain function\, and
  disturbed neurogenesis has been associated with diseases such as major de
 pression and epilepsy. A tight regulation of NSPC quiescence and prolifera
 tion is crucial to ensure life-long neurogenesis and prevent exhaustion or
  uncontrolled growth of the stem cell pool. What regulates this delicate b
 alance is not fully understood. We are interested in how cellular metaboli
 sm is influencing NSPC activity and how metabolic programs change between 
 quiescent and proliferating NSPCs and their differentiating progeny. We ha
 ve shown that de novo lipogenesis is crucial for proper NSPC proliferation
  and integration and have identified the protein Spot14 as a novel functio
 nal marker for the most quiescent NSPC population in vivo1\,2. We have fur
 ther studied how Spot14 is keeping NSPCs quiescent through the regulation 
 of lipid metabolic pathways. We have exciting data showing that quiescent 
 NSPCs depend on the breakdown of lipids via fatty acid oxidation (FAO)\, t
 hat inhibition of FAO in vitro and in vivo results in altered NSPC behavio
 r and that changing the levels of a single metabolite is sufficient to ove
 rride quiescence cues3. Taken together\, we show an instructive role for f
 atty acid metabolism in regulating NSPC activity in the adult brain.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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