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SUMMARY:Special LMNN SEMINAR // Epigenetics: the third pillar of nitric ox
 ide signaling
DTSTART:20170627T090000
DTEND:20170627T100000
DTSTAMP:20260510T235120Z
UID:031a031c2e3be3f3cc6437d993ed14de2c4ba5cbf5e6d3f428e47464
CATEGORIES:Conferences - Seminars
DESCRIPTION:Douglas D. Thomas\, Department of Medicinal Chemistry and Phar
 macognosy\, College of Pharmacy\, The University of Illinois at Chicago\, 
 Chicago\, USA\nNitric oxide (NO)\, the endogenously produced free radical 
 signaling molecule\, is generally thought to function via its interactions
  with heme-containing proteins\, such as soluble guanylyl cyclase (sGC)\, 
 or by the formation of protein adducts containing nitrogen oxide functiona
 l groups (such as S-nitrosothiols\, 3-nitrotyrosine\, and dinitrosyliron c
 omplexes). Of the numerous purported NO signaling mechanisms\, epigenetic 
 regulation has gained considerable interest in recent years. There is now 
 abundant experimental evidence to establish NO as an endogenous epigenetic
  regulator of gene expression and cell phenotype.  We have demonstrated t
 hat NO can influence key aspects of epigenetic regulation that include his
 tone posttranslational modifications\, DNA methylation\, and microRNA leve
 ls.  Studies on various cancers have observed NO-mediated regulation of e
 pigenetic protein expression and enzymatic activity resulting in remodelin
 g of the epigenetic landscape to ultimately influence gene expression. In 
 addition to the well-established pathways of NO signaling\, epigenetic mec
 hanisms provide much-needed explanations for poorly understood context-spe
 cific effects of NO. These findings provide more insight into the molecula
 r mechanisms of NO signaling and increase our ability to dissect its funct
 ional role(s) in specific micro-environments in health and disease. Our re
 sults establish that NO functions as an epigenetic regulator of gene expre
 ssion mediated by changes in the epigenetic landscape (the “third pillar
 ” of NO signaling).\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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