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SUMMARY:BMI EXTRAORDINARY SEMINAR // “Neural circuits supporting incenti
 vized inhibition”
DTSTART:20170508T151500
DTEND:20170508T161500
DTSTAMP:20260530T140854Z
UID:aaf0bf75c95e3c52b68e74885e577e94e37f967e6002986bb3432dff
CATEGORIES:Conferences - Seminars
DESCRIPTION:Brian Knutson\, Psychology and Neuroscience\, Stanford Univers
 ity\, USA  \nThe ability to withhold responses under high stakes\, or “
 incentivized inhibition\,” is critical for impulse control. Previous res
 earch suggests that right ventrolateral prefrontal cortex (VLPFC) is essen
 tial for motor inhibition\, but less research has addressed how incentives
  influence this inhibition. By combining a novel task with diffusion-weigh
 ted and functional magnetic resonance imaging\, we identified neural circu
 its that support incentivized inhibition. Behaviorally\, high incentives i
 ncreased responses to obtain money\, but the same incentives decreased res
 ponse inhibition. Structurally\, individual differences in the coherence o
 f a newly-characterized white-matter tract connecting the VLPFC and anteri
 or insula (AIns) were positively associated with incentivized inhibition p
 erformance. Functionally\, right VLPFC and AIns activity were positively a
 ssociated with incentivized inhibition performance\, and further\, VLPFC a
 ctivity mediated the association between tract coherence and incentivized 
 inhibition performance. Together\, these multimodal findings support a new
  account of how people inhibit actions when stakes are high.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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