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SUMMARY:Transcriptional blueprint for  becoming a new neuron in the cerebr
 al cortex
DTSTART:20170509T121500
DTEND:20170509T130000
DTSTAMP:20260922T040712Z
UID:9e87394a3340b0922b992d567a671b1e9651570fa2034dfe340ffce9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Subashika Govindan\nUniversité de Genève\n\n \nDespite t
 he mounting evidence on how different genes regulate different aspects of 
 cortical neurogenesis\, the genetic program that drives acquisition and ma
 intenance of  neuronal identity upon progenitor division is unknown.It is
   important to dissect the proper sequence of molecular events that occur
 s during acquisition of specific neuronal identity to understand how the b
 rain is built.\n \n A major limitation in studying this has been the ina
 bility to specifically identify\, access and track specific cohort of neur
 ons from their time of birth in vivo with the requisite temporal resolut
 ion. To overcome this obstacle\, I have developed and standardized a novel
  technique “FlashTag” that enables precise in vivo tagging of neuron
 s and progenitors from the time of mitosis. By combining FlashTag” techn
 ology with single-cell RNA sequencing\, we have identified and functionall
 y characterized neuron-specific primordial transcriptional programs as the
 y dynamically unfold in vivo during the first forty-eight hours followin
 g mitosis.\n\nOur results provide a detailed functional account of early n
 euronal life\, including the discovery of successive “transcriptional wa
 ves” that organize the temporal sequence of cellular differentiation eve
 nts. This high-resolution dynamic blueprint of neuronal specification can 
 identify the transient molecular events that guide a neuron towards its fi
 nal fate\, and contribute to a roadmap for the reverse engineering of spe
 cific classes of cortical neurons from undifferentiated cells. Additionall
 y such map will be key to understand what are the molecular pathways that 
 are altered in disease conditions. \n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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