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SUMMARY:X-Ray Crystal Structure of a Chromatosome—the Fundamental Nucleo
 some-Linker Histone Assembly of Chromatin
DTSTART:20170622T110000
DTEND:20170622T123000
DTSTAMP:20260427T231135Z
UID:96abe92a6230b5ba4f7ff8cdfc2c327db7b116d52579866cec704eac
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Curtis Davey (NTU - Singapore)\n Prof. Davey fundamenta
 l research interest focuses on understanding the structural and dynamical
  features of chromatin assembly and how this could yield unique therapeut
 ic possibilities. Davey’s lab has analyzed nucleosome structure and st
 ability with many different DNA fragments to derive a general mechanical m
 odel that helps explain and predict the sequence-dependent properties of 
 this system. His lab studies how nucleosomes and chromatin fiber are reco
 gnized and influenced by metals\, xenobiotics\, drugs and therapeutic can
 didates as well as by nuclear proteins\, such as DNA repair\, apoptotic
  and developmental transcription factors. Davey’s lab is working on ad
 duct structure\, site selectivity\, modulatory and reaction mechanism prin
 ciples for a variety of chromatin-binding agents\, such as metal-based an
 ticancer agents\, which\, together with understanding how macromolecules
  recognize specific chromatin states\, can reveal novel genomic regulat
 ory features\, and allow  to engage in directed drug design. 
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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