BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Applying Multi-Organ-on-a-Chip Technologies for Predictive Substan
 ce Testing
DTSTART:20170515T121500
DTEND:20170515T133000
DTSTAMP:20260406T103742Z
UID:587d490c4f9244cc44bcc9b7acb14f69e95f8215ff991b1082859b2a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Ing. Reyk HORLAND\, TissUse GmBH\, Berlin (D)\nBIOENGINEER
 ING SEMINAR\n\nAbstract:\nCurrent in vitro and animal tests do not reliabl
 e predict the human responses to drugs or substances because they are fail
 ing to emulate the organ complexity of the human body\, leading to high at
 trition rates in clinical studies. For example\, absorption\, distribution
 \, metabolism and excretion (ADME) are key factors for predicting safety a
 nd efficacy of therapeutic candidates. However\, these systemic effects ar
 e ignored in most in vitro tests. In order to emulate the physiological re
 levant in vivo crosstalk with the ability to perform systemic substance te
 sting\, we have developed a universal Multi‑Organ-Chip platform for long
 -term culture of human organ equivalents interconnected within a common ca
 pillary microfluidic network. The on-chip micro-pump ensures stable long-t
 erm circulation of media through the tissue culture compartments at variab
 le flow rates\, adjustable to physiological mechanical stresses of the res
 pective tissues. This talk will present examples of current organ combinat
 ions and how the advanced knowledge and experience acquired will eventuall
 y enable the development of a Human-on-a-chip system. In addition\, the qu
 estion of how to qualify and validate these systems will be addressed.\n\n
 Bio:\nSince 2010 Reyk Horland is actively involved in the development of T
 issUse GmBH’s Multi-Organ-Chip platform for culture analysis of drug can
 didates\, cosmetics\, chemicals and consumer products. He currently holds 
 the position of Head (VP) of Business Development at TissUse.\nPrior to Ti
 ssUse Reyk studied Biotechnology at the Technische Universität Berlin and
  specialized in Medical Biotechnology. During his academic career he was i
 nvolved in various tissue engineering programs\, all with a focus on comme
 rcialisation of the respective products.
LOCATION:BC 02 https://plan.epfl.ch/?room==BC%2002
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR