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SUMMARY:Coupling cell mechanics and functions in neurons
DTSTART:20120207T140000
DTSTAMP:20260509T131803Z
UID:7b5ae9bc813ad804867c41f38495206253169acd9babcbe09595cf81
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Antoine Jerusalem\,  IMDEA Materials Institute\,  Madrid\n
 The field of computational cell mechanics encompasses different scales ran
 ging from individual monomers\, cytoskeleton constituents\, up to the full
  cell. Its focus\, fueled by the development of interdisciplinary collabor
 ative efforts between engineering\, computer science\nand biology\, until 
 recently relatively isolated\, has allowed for important breakthroughs in 
 biomedicine\, bioengineering or even neurology. Among all cells\, neurons 
 are at the heart of tremendous medical challenges (traumatic brain injurie
 s\, Alzheimer’s disease\, etc.). In nearly all of these challenges\, the
  intrinsic coupling between mechanical and chemical mechanisms in the neur
 on is of drastic relevance. This presentation aims at highlighting the rel
 evance of\nsuch coupling through significant examples linked to neuronal g
 rowth and health\, as well as during damaging events such as TBI and Alzhe
 imer’s disease. To this end\, both Finite Element and Finite Difference 
 Methods (including our in-house code Neurite) are used. In the first examp
 le\, blast effects on the health of an individual cell and its intrinsic b
 iostructures are studied\; the second example will focus on a new function
 al damage criterion for white matter myelinated axon and its effect on the
  electrical propagation along the axon\; and a third example will deal wit
 h axonal growth and its relation with the axon mechanical properties.
LOCATION:ME B3 31
STATUS:CONFIRMED
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