BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Heating and Eating: a Role of Brown Fat in the Control of Food Int
 ake
DTSTART:20170602T123000
DTEND:20170602T133000
DTSTAMP:20260916T202608Z
UID:8b2184484d2b76f4c9360326b2a03247bb41786a4376bedb58cf3400
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Martin Klingenspor\, Technical University Munich (D)\n 
 \nBIOENGINEERING SEMINAR\n\nAbstract:\nDuring the past 10 years mammalian 
 adipose tissue biology has received considerable attention. Major progress
  was made in elucidating the developmental origin of adipocytes\, the hete
 ro­geneity and functional plasticity of adipose tissues\, and the metabol
 ic activity of human adipose tissues. In addition to heat dissipation in b
 rown fat\, the formation of thermogenic brown-like adipocytes can be induc
 ed by physiological and pharmacological stimuli in white fat. In animal mo
 dels for obesity and diabetes\, the formation of brown and brown-in-white 
 (brite) fat has beneficial metabolic effects. In adult human subjects acti
 vation of brown/brite fat is regularly observed upon cold exposure\, but i
 s attenuated with increasing age and BMI. In obese and diabetic patients w
 ith low brown/brite fat activity\, catabolic activity can be reactivated b
 y periods of cold acclimation associated with improved metabolic profile. 
 Therefore\, the recruitment and activation of thermogenic brown/brite adip
 ocytes in human adipose tissues as a treatment for metabolic disease is of
  prime interest.\nMost research on brown/brite fat concentrates on the ene
 rgy sink function\, with less attention directed towards a possible role o
 f this heater organ in the regulation of energy intake. In the last centur
 y lipostatic\, glucostatic\, and thermostatic hypotheses on the control of
  food intake were put forward. Revitalizing these old concepts\, meal-asso
 ciated heat dissipation in brown fat induced by the sympathetic innervatio
 n was suggested to play a key role in thermoregulatory feeding. In support
 \, beta-3-adrenergic stimulation of brown fat inhibits food intake. Alike 
 cold-induced activation\, several reports demonstrate single meal-induced 
 increase in glucose and fatty acid uptake in brown/brite fat of rodents an
 d humans. Moreover\, maximal brown fat activity coincides with meal termin
 ation. Sensory innervation\, adipokines secreted from brown fat or heat as
  such could feedback information to the brain and promote satiation. This 
 talk will present evidence for a role of brown fat in the control of food 
 intake. \n\nBio:\nAfter studying biology (1994)\, Prof. Klingenspor did h
 is doctorate at Philipp University of Marburg. Thanks to a research grant 
 from the German Research Foundation (DFG) (1995/96)\, he went to work unde
 r Prof. Karen Reue at West Los Angeles VA Medical Center (USA). He returne
 d to Marburg to complete his lecturer qualification (2001) in zoology and 
 animal physiology. He became deputy head of that university’s Department
  of Animal Physiology (2004). In 2007\, he became Chair of Molecular Nutri
 tional Medicine at the Technical University Munich (TUM). Prof. Klingenspo
 r is an appointed expert in various German and international research orga
 nizations. He is the co-editor of the American Journal of Physiology – R
 egulatory\, Integrative and Comparative Physiology.\n\nProf. Klingenspor (
 b. 1961) researches the mechanisms of metabolic regulation with the aim of
  identifying how nutrition affects the body’s energy balance\, i.e. the 
 balance between energy intake and energy expenditure. His work centers on 
 examining regulation of the efficiency of energy conversion in mitochondri
 a as the powerhouses of eukaryotic cells.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR