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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Single-Cell Gene Regulatory Networks
DTSTART:20170703T121500
DTEND:20170703T131500
DTSTAMP:20260407T064400Z
UID:c2558024d95663e0dfcf62902cdbd3e1afae641f0a0ebcb3c78be980
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Stein Aerts\, VIB/ KU Leuven Center for Brain & Disease 
 Research\, Campus Gasthuisberg\, Leuven (B)\nDISTINGUISHED LECTURE IN BIOL
 OGICAL ENGINEERING\n\nAbstract:\nSingle-cell transcriptomics and single-ce
 ll epigenomics allow building cell atlases of any given tissue and infer t
 he dynamics of cellular state transitions during developmental or disease 
 trajectories.\n\nIn the first part of my talk I will describe a single-cel
 l atlas of the ageing Drosophila brain\, for which we profiled more than 3
 0.000 single cells with Drop-seq and 10X Chromium. Using a new bioinformat
 ics method we developed\, called SCENIC (Single Cell rEgulatory Network In
 ference and Clustering)\, we identified transcription factors\, networks\,
  and cell states of glutamatergic\, cholinergic\, gabaergic\, dopaminergic
 \, and mushroom body neurons\, as well as various glial cell types includi
 ng astrocytes and perineural glia.\n\nIn the second part of my talk I will
  describe a single-cell ATAC-seq data set we generated in the Drosophila e
 ye imaginal disc. Using another new bioinformatics method\, called cisTopi
 c\, we overcome the sparsity of these data\, identifying relevant regulato
 ry programs and stable cell states in the normal tissue\, as well as in a 
 Drosophila tumour model. Altogether\, I will discuss various examples and 
 computational methods to trace genomic regulatory programs at single-cell 
 resolution.\n\nBio:\nResearch positions:\n\n	Associate Professor and Princ
 ipal Investigator of the Laboratory of Computational Biology\, School of M
 edicine\, University of Leuven (2009-)\n	Postdoc at VIB\, Bassem Hassan la
 b (2005-2009)\, Leuven\n	Visiting postdoc at Developmental Biology Institu
 te of Marseille\, Luminy (IBDML)\, Marseille\, France (2006)\, with Denis 
 Thieffry and Carl Herrmann\n	PhD Bioinformatics\, School of Engineering (E
 SAT)\, University of Leuven (2001-2004)\n	Bioinformatician\, Data4s Future
  Technologies NV (2000-2001)\n	Assistant IT Project Leader Janssen Pharmac
 eutica\, Johnson&Johnson (1999-2000)\n	Visiting undergraduate researcher a
 t the Center for Genomic Sciences\, Cuernavaca\, Mexico (Jul-Nov 1998)\, w
 ith Esperanza Mart’nez-Romero.\n\nEducation:\n\n\n	PhD in Engineering (B
 ioinformatics)\, Department of Electrical Engineering ESAT-SCD\, Universit
 y of Leuven (2004)\n	Advanced Studies in Applied Computer Science\, Univer
 sity of Brussels (2002)\n	Master in Bioscience Engineering (Molecular Biol
 ogy)\, University of Leuven (1999)\n
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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