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SUMMARY:Do lincRNAs Contribute to Mouse Embryonic Stem Cell Cycle Adaptati
 ons?
DTSTART:20170822T113000
DTEND:20170822T123000
DTSTAMP:20260511T204818Z
UID:46837ffae481858818b4c14e9a5027998fd314cc1eaa8337987a0be3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ana Claudia Marques\, University of Lausanne (CH)\nBIOEN
 GINEERING SEMINAR\n\nAbstract:\nIntergenic long noncoding RNAs (lincRNAs) 
 are the largest class of transcripts in the human genome and their transcr
 iption is pervasive in higher eukaryotes. Functional and evolutionary anal
 yses together with extensive characterization of a handful of lincRNAs sup
 port the general consensus that these transcripts contribute to the regula
 tion of gene expression programs and some can impact normal and disease ph
 enotypes.\n\nRecently a number of lincRNAs have been shown to contribute t
 o cell cycle progression. Given that most lincRNA expression is spatially 
 and temporally restricted\, we hypothesized that they would contribute to 
 cell-type specific modulation of this process. To test this hypothesis\, w
 e focused on the contributions of lincRNAs to embryonic stem cell cycle be
 cause compared to differentiated cells the embryonic stem cell cycle is ch
 aracterized by a truncated G1 phase and an elongated S phase. We used sing
 le cell RNA-sequencing data for mouse embryonic stem cells staged at G1\, 
 S\, or G2/M cell cycle phases to identify genes differentially expressed b
 etween these stages. We found that lincRNAs are enriched within differenti
 ally expressed genes suggesting their expression is more tightly controlle
 d than that of mRNAs during this key cellular process. Cell cycle associat
 ed lincRNAs are co-expressed with protein-coding genes with established ro
 les in cell cycle progression and experimental evidence supports the role 
 some of these transcripts in the modulation of the levels of key cell cycl
 e regulators and influence cell cycle progression. Importantly 70% of cell
  cycle-associated lincRNAs are differentially expressed between G1 and S s
 uggesting they can contribute to the maintenance of the short G1 phase and
  a high proportion of cells in S phase that characterize embryonic stem ce
 ll cycle. Consistent with this hypothesis G1/S differential expressed linc
 RNAs are more cell type specific than other cell cycle associated lincRNAs
  and frequently genetically interact with genes involved in maintenance of
  pluripotency. Experimental and computational validation of this hypothesi
 s is currently ongoing.\n\nIn summary our data suggests that lincRNAs cont
 ribute to the mouse embryonic stem cell cycle adaptations.\n\nBio:\nAfter 
 obtaining her diploma in Chemical Engineering from the Technical Universit
 y of Lisbon\, Ana Marques decided to pursue her interest in the molecular 
 basis of human traits. In 2003\, she started her PhD under the supervision
  of Henrik Kaessmann at the University of Lausanne. During her graduate st
 udies she investigated the contribution of gene duplication to the origin 
 and evolution of human phenotypes. In 2008 she joined Chris Ponting’s gr
 oup as a post-doctoral fellow to work on the origin and evolution of inter
 genic lncRNAs. Her postdoctoral training was funded by SNF\, FCT and Marie
  Curie fellowships. In 2012\, she was awarded a Research Fellowship (The R
 oyal Society) and started developing an independent research program on th
 e biological and molecular functions of intergenic lncRNAs. Ana Marques ha
 s been a Swiss National Science Foundation Professor since October 2014\, 
 when she set up lab at UNIL’s Department of Physiology. She is currently
  a member of the UNIL's Department of Computational Biology.
LOCATION:AI1153 https://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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