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PRODID:-//Memento EPFL//
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SUMMARY:The emergence of contractility in biological fiber networks
DTSTART:20170621T140000
DTEND:20170621T150000
DTSTAMP:20260916T065538Z
UID:5e40a957a5b9c5863a330f435bf14588e601da8e2f1ba25f55bae977
CATEGORIES:Conferences - Seminars
DESCRIPTION:Pierre Ronceray\nLarge-scale force generation is essential for
  biological functions such as cell motility\, embryonic development\, and 
 muscle contraction. In these processes\, active forces generated at the mo
 lecular level by motor proteins are transmitted by disordered fiber networ
 ks\, resulting in large-scale contractile stresses. I will present a compr
 ehensive theoretical study of force transmission in these networks. While 
 the linear response to small forces is remarkably simple\, taking into acc
 ount the nonlinear properties of the filaments yields strikingly counter-i
 ntuitive effects such as the reversal of extensile forces into contractile
  ones. These forces are furthermore amplified as they induce buckling on l
 arge scales in the network\, resulting in large tensile stresses at the ma
 croscopic scale. We develop a new experimental technique\, termed Nonlinea
 r Stress Inference Microscopy\, to measure stresses in biological media\, 
 and show that it reveals this force amplification in reconstituted tissues
 . These results shed light on the role of the network microstructure in sh
 aping active stresses in cells and tissue
LOCATION:BSP 727 https://plan.epfl.ch/?room==BSP%20727
STATUS:CONFIRMED
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