BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:Iron Oxide Nanoparticles for medical application: still a challeng ing task for materials research DTSTART:20171218T131500 DTEND:20171218T141500 DTSTAMP:20260416T071236Z UID:bcd176993d7cd8f6843fb43b0db23dc3f3abb3dcf74facabe9d9b763 CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. Heinrich Hofmann\, EPFL\nIron oxide nanoparticles have b een in development for medical applications for more than 20 years. In the mean time\, several products were on the market and used in clinics as a contrast agent for MRI or as a drug for the successful treatment of anemia . For economic reasons\, iron oxide as a contrast agent disappeared from t he market\, because it was only accredited for the imaging of liver. Today the most useful development of superparamagnetic iron oxide is\, besides imaging\, in the field of magnetic fluid hyperthermia. Particles injected locally into the tumor are efficient heat sources if an external alternate magnetic field is applied. To bring iron oxide nanoparticles to the clini cs\,  properties like saturation magnetization\, magnetic anisotropy\, co lloidal stability\, biocompatibility and especially  targeting has to be strongly improved. In addition to these parameters\, biological properties like biodistribution and residence time have to be adapted to the clinica l needs. All these properties can only be improved if the behavior of the particles is well understood\, both from the physical as well as the biolo gical side.\n\nIn this talk\, a short introduction of the state of the art will be given\, followed by an analysis of the gaps still existing\, incl uding some propositions for how to overcome them. The focus of the talk wi ll be the physico-chemical properties and\, in addition to typically mater ials developments\, the impact of translational research on materials deve lopment will be highlighted.\n \nReferences:\nControlling structural and magnetic properties of IONPs by aqueous synthesis for improved hyperthermi a\nBy: Bonvin\, Debora\; Arakcheeva\, Alla\; Millan\, Angel\; et al.\,\nRS C ADVANCES   Volume: 7   Issue: 22   Pages: 13159-13170   Publishe d: 2017\n \nAssessing the In Vitro and In Vivo Toxicity of Superparamagne tic Iron Oxide Nanoparticles\,  Mahmoudi\, Morteza\; Hofmann\, Heinrich\; Rothen-Rutishauser\, Barbara\; et al.\nCHEMICAL REVIEWS   Volume: 112    Issue: 4   Pages: 2323-2338   Published: APR 2012\n \nNanoparticle s in medicine: Current challenges facing inorganic nanoparticle toxicity a ssessments and standardizations\,  Hofmann-Amtenbrink\, Margarethe\; Grai nger\, David W.\; Hofmann\, Heinrich\nNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE   Volume: 11   Issue: 7   Pages: 1689-1694  Published: OCT 2015\n\nBio: Hofmann Heinrich\, studied first foundry engineering at the Applied University of Duisburg followed by a study of Material Science and Engineering at the Technical University of Berlin. 1983 he got his Ph D in Material Science with a thesis prepared at the Powder Metallurgy Labo ratory at the Max Planck Institute in Stuttgart. Between 1983 and 1985\, h e was senior scientist at MPI working on novel hard metals.  In 1985 he j oined the R&D center of Alusuisse-Lonza\, at Neuhausen-am-Rheinfall\, deve loping new ceramic powders. In 1993 he joined EPFL\, his research area inc ludes the synthesis of nanostructured materials based on nanoparticles and the modification of surfaces with nanoparticles using colloidal methods. Main topics of his research today are synthesis and functionalisation of n anoparticles for medical applications He is member of several professional organizations as well as of the “European Academy for Technology Assesm ent” and Member of the Swiss working group “Nanoregulation”. Since 2 014 he is advisor for nanotechnology at the Human Medicines Expert Committ ee of the Swiss Agency for Therapeutic Products\, Swissmedic. LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201 STATUS:CONFIRMED END:VEVENT END:VCALENDAR