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SUMMARY:The challenge of cellular resolution in the living eye
DTSTART:20170724T133000
DTEND:20170724T150000
DTSTAMP:20260427T230904Z
UID:57db2b058a235a17790d83084d34abfda5442b3731c2320ed08b8fe3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Rainer Leitgeb\, Medical University of Vienna\nImaging t
 he human retina in-vivo with high resolution of enormous interest not only
  in ophthalmology but also in neurology. As the retina can be seen as exte
 nsion of the brain's neural  tissue\, it is straightforward to assume tha
 t the retina is equally affected by neurodegenerative diseases-  casting 
 the phrase of “the eye as window to the brain”. Despite the elegance o
 f non-invasive diagnosis of brain diseases\, achieving high resolution nee
 ds to overcome the significant aberrations introduced by the imperfect ocu
 lar optics\, as well as motion artifacts. The first issue has only been so
 lved through expensive adaption of adaptive optics methods in ocular imagi
 ng. However\, mainly two dimensional sections of the retina have been imag
 ed with high resolution. But the  combination of AO with optical coherenc
 e tomography (OCT) promises to achieve high isotropic resolution in all th
 ree dimensions. In a recent work we demonstrated how to achieve in a pure 
 computational manner aberration correction of retinal images operating on 
 OCT data in 3D. A remaining challenge are motion artifacts\, which can onl
 y be properly managed through increased acquisition speed. For this task w
 e first demonstrate small field-of-view imaging with a scanning OCT system
 . We then show how the FOV can be extended by switching to line field illu
 mination and detection. Further gain in speed is achieved by a line field 
 holography method with up to 100Hz en-face image rate. Finally we demonstr
 ate how computational AO also provides high resolution angiography images 
 without the need of contrast agents.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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