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SUMMARY:Mechanics of Blastocyst Morphogenesis
DTSTART:20170816T150000
DTEND:20170816T160000
DTSTAMP:20260925T123638Z
UID:708fd2eea44de7707fbf698a0cc9d4d41f99764483290457861db9e2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jean-Léon Maître\, Ph.D.\, Institut Curie\, Paris (F)\nBIOEN
 GINEERING SEMINAR\n\nAbstract:\nDuring pre-implantation development\, the 
 mammalian embryo forms the blastocyst\, which will implant into the uterus
 . The architecture of the blastocyst is essential to the specification of 
 the first mammalian lineages and to the implantation of the embryo. Consis
 ting of an epithelium enveloping a fluid-filled cavity and the inner cell 
 mass\, the blastocyst is sculpted by a succession of morphogenetic events.
  These deformations result from the changes in the forces and mechanical p
 roperties of the tissue composing the embryo.\n\nUsing microaspiration\, l
 ive-imaging\, genetics and theoretical modelling\, we study the biophysica
 l and cellular changes leading to the formation of the blastocyst. In part
 icular\, we uncover the crucial role of acto-myosin contractility\, which 
 generates periodic waves of contractions\, compacts the embryo\, controls 
 the position of cells within the embryo and influences fate specification.
 \n\nBio:\n2016 - current\nGroup leader at Institut Curie (Paris\, F) in th
 e Genetics and Developmental Biology unit CNRS UMR3215\, INSERM U934\n\n20
 13 - 2016\nPostdoc fellow in the Hiiragi Lab at the European Molecular Bio
 logy Laboratory (Heidelberg\, D)\n\n2007 - 2012\nPhD student in the Heisen
 berg Lab at the Max Planck Institute for Cell Biology and Genetics (Dresde
 n\, D) and the Institute of Science and Technology Austria (Klosterneuburg
 \, AT)\n\n2006 - 2007\nMaster student in the Génot Lab at the Institut Eu
 ropéen de Chimie et Biologie (Pessac\, F)\n\n2006\nMaster student in the 
 Martinez-Arias Lab at the University of Cambridge (UK)\, in the Dept. of G
 enetics\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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