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SUMMARY:Conceptual design of a process to produce pyridine bases
DTSTART:20170823T100000
DTEND:20170823T110000
DTSTAMP:20260427T225850Z
UID:4d9b792b2fa3c147c7a66893c0d2084282c90bb74fdebf68891a8382
CATEGORIES:Conferences - Seminars
DESCRIPTION:Emanuele Moioli Institute for Chemical Reaction Engineering\, 
 Friederich-Alexander-Universität Erlangen\, Germany\nPyridine bases play 
 an important role in the fine chemical industry. These compounds are impor
 tant intermediates in the production of vitamins\, resins and agrochemical
 s. The aim of this work is to develop a new process to synthesize 2-Methyl
 -5-Ethylpyridine (MEP). MEP is currently produced by liquid phase reaction
  of paraldehyde (2\,4\,6-Trimethyl-1\,3\,5-trioxane) in the presence of am
 monia and acetic acid. The reaction is characterized by long residence tim
 e and high operative pressure. Additionally\, an increase in concentration
  decreases the selectivity to MEP. A new reaction scheme is developed star
 ting from acetaldehyde ammonia trimer (Hexahydro-2\,4\,6-trimethyl-1\,3\,5
 -triazine)\, which allows reducing the residence time and does not require
  direct addition of ammonia solution in the reactor\, while maintaining ac
 etic acid as catalyst. Characterization and feasibility of the reaction we
 re assessed and a kinetic model was developed in an ideal reactor\, to hav
 e the base for a rational reactor design. The pilot reactor was developed 
 considering the following model criteria: fast heating phase\, effective t
 emperature control\, good distribution of the reactant and good contact be
 tween reactant and catalyst. The reaction was carried out in a continuous 
 coil reactor to assess the possibility of process scale up. Although the r
 equirements concerning heat management were achieved\, the operation was l
 imited by mass transfer effects. This happens because the reaction is comp
 leted before the solutions containing reactant and catalyst are fully mixe
 d. The insertion of a specific mixing unit before the reactor resulted the
  best solution to prevent this mass transfer problem. The optimal manageme
 nt of mixing generates the best process conditions assuring the highest pr
 oductivity.\n 
LOCATION:Zeuzier
STATUS:CONFIRMED
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