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SUMMARY:New Insights into Hydrophobic Interactions Encoded by Chemical Nan
 opatterns
DTSTART:20171120T131500
DTEND:20171120T141500
DTSTAMP:20260510T105745Z
UID:122fca73e43f3e2e309ddcd1d5c20bffac69eb2da4445a914f72bedf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Nicholas L. Abbott\, University of Wisconsin-Madison USA
 \nThe structuring of water near non-polar molecular fragments or surfaces 
 mediates cohesive interactions (so-called hydrophobic interactions) that u
 nderlie a broad range of biophysical and materials-related phenomena.  Su
 bstantial progress has been made during the past decade towards understand
 ing hydrophobic interactions in simple model systems\, but in most biologi
 cal and technological contexts\, non-polar domains are found in close prox
 imity to polar and charged functional groups.  We are using conformationa
 lly-stable b-amino acid oligomers\, and single-molecule force measurements
  to elucidate hydrophobic interactions encoded by specific chemical nanopa
 tterns. These measurements reveal\, for example\, that ions immobilized ad
 jacent to non-polar domains can substantially increase or decrease the str
 ength of hydrophobic adhesion\, with the effect strongly dependent on the 
 specific ion type.  This understanding is providing a fresh starting poin
 t for molecular design in aqueous environments in a broad range of context
 s.\n \nMa\, C.D.\; Wang\, C.\; Acevedo-Vélez\, C.\; Gellman\, S.H.\; Abb
 ott\, N.L.\, “Modulation of Hydrophobic Interactions by Proximally Immob
 ilized Ions”\, Nature\, 517(7534)\, 347-443\, 2015.\n\nBio: Nicholas Abb
 ott received a Bachelor of Engineering (Chemical Engineering) from Univers
 ity of Adelaide\, Australia in 1985\, and a PhD in Chemical Engineering fr
 om Massachusetts Institute of Technology in 1991.  He was a postdoctoral 
 fellow in the Chemistry Department of Harvard University from 1991-1993. 
  He is currently the Sobota Professor and Hilldale Professor of Chemical 
 and Biological Engineering at University of Wisconsin-Madison\, and the Di
 rector of the Wisconsin Materials Research Science and Engineering Center.
   He is an elected Member of the US National Academy of Engineering and s
 erves as Co-Editor-in-Chief of Current Opinion in Colloid and Interface Sc
 ience.\n\n \n 
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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