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SUMMARY:Strategic design of drug core structure - from natural molecules t
 o non-natural molecules
DTSTART:20170920T103000
DTSTAMP:20260917T070532Z
UID:73c3f22365fba0ccbd3ee04fc458f3a18d1235c1fd9580dee2b5f342
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Masami Otsuka\, Kumamoto University (Jap)\nWe have been 
 engaged in the design\, synthesis and evaluation of biologically active mo
 lecules. We have synthesized numerous molecules of various structure with 
 miscellaneous activity. Now I describe what we have done from the strategi
 c viewpoint.\n \n1.     From Natural Bleomycin to Non-Natural Bleomyc
 in\n1.1   What is Bleomycin\n1.2   How we designed Non-Natural Bleomyc
 in\n1.3   Simplification of Bleomycin Structure\n1.4   Symmetrization 
 of the Metal Core\n1.5   New Function: Zinc Protein Inhibition\n1.5.1. Z
 inc Finger Protein\n1.5.2. Farnesyltransferase\n1.5.3. HIV-1 Vif vs Host P
 rotein APOBEC3G\n1.6. Application to Chronic Inflammation\n1.6.1. Cancer M
 etastasis\n1.6.2. Crohn’s Disease\n1.6.3. Systemic Sclerosis\n \n2.  
    From Natural Inositol Phospholipids to Non-Natural Inositol Phospholi
 pids\n2.1. Biotinylated Inositol Phosphate\n2.2. PLCd PH Domain Interactio
 n\n2.3. HIV and Inositol Phospholipid\n2.4. Towards the Eradication of AID
 S\n \nBio:\nProf. Masami Otsuka got his Ph.D from University of Tokyo in 
 1983. He did a postdoctoral research fellow at Oxford University in the gr
 oup led by Professor Jack E. Baldwin. From 1997\, he started his professor
 ship in the Faculty of Pharmaceutical Sciences in Kumamoto University\, an
 d headed the School of Pharmacy\, Graduate School of Pharmaceutical Scienc
 es between 2011-2014. Since 2013\, Prof. Otsuka serves as the vice preside
 nt of the Pharmaceutical Society of Japan.\n \nHis current research theme
 s focus on synthetic study of biofunctional artificial compounds and natur
 al products\,  and molecular virological study of HIV.
LOCATION:BM 1130 https://plan.epfl.ch/?room==BM%201130
STATUS:CONFIRMED
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