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SUMMARY:Type 2 immunity: a protagonist of protection\, tissue repair and m
 etabolism
DTSTART:20171114T123000
DTSTAMP:20260506T080354Z
UID:7ef9427a1ef616a31388497d1288dfae2ca152437cb0862c4b7741df
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Nicola HARRIS\, Laboratory of Intestinal Immunology (UPH
 ARRIS)\, Global Health Institute\, EPFL\nType 2 immunity is a highly compl
 ex system characterized by the expansion of lymphoid cells producing inter
 leukin (IL)-4\, IL-5 and IL-13\, and the recruitment/activation of myeloid
  cells including eosinophils\, basophils\, mast cells and alternatively-ac
 tivated macrophages (AAM). Much of our understanding of type 2 immune resp
 onses derives from the pathological role of this response in driving aller
 gies\; however\, the physiological role of type 2 immunity is assumed to b
 e the control of helminth parasites. Although these organisms have largely
  been eradicated in many parts of the world\, people living within tropica
 l areas without adequate access to sanitation continue to suffer from ende
 mic infection\, with current estimates indicating an approximate 2.5 billi
 on people infected worldwide.  Although the role of type 2 immunity in pr
 otection against parasites has long been appreciated\, the effector mechan
 isms leading to parasite killing have remained unclear and recent evidence
  suggests type 2 immunity is equally critical for the timely repair of tis
 sues damaged by parasite migration. Lastly\, type 2 immunity has emerged a
 s an important regulator of host physiology and metabolism and may play ad
 ditional roles in perinatal adaptation of mucosal tissues to the external 
 environment. Thus\, the implications of type 2 immune responses upon healt
 h and disease are far-reaching with impacts protective immunity\, tissue r
 epair and metabolism.\n\nOur laboratory has been actively engaged all each
  of these aspects of type 2 immunity with a particular focus on the intest
 ine and intestinal helminths. \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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