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SUMMARY:Neuromesodermal Progenitors are Conserved Source of Spinal Cord wi
 th Divergent Growth Dynamics
DTSTART:20171012T100000
DTEND:20171012T110000
DTSTAMP:20260407T144148Z
UID:5daa5c2e4e1916d978666467730bb6f2c85553fb44000487eefee8dd
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ben Steventon\, Ph.D.\, University of Cambridge (UK)\nBIOENGI
 NEERING SEMINAR\n\nAbstract:\nGastrulation is the process by which cells o
 f the early embryo become specified into distinct germ layers. Recently\, 
 retrospective clonal analysis studies in the mouse have demonstrated that 
 germ layer specification continues throughout somitogenesis stages from a 
 population of bipotent stem cells called neuromesodermal progenitors (NMps
 ). However\, it is not clear whether this is a later adaptation of mammali
 an embryos that elongate their body axis by continual addition of cells fr
 om a posterior growth zone or represents a conserved cellular trajectory o
 f spinal cord production. Via a combination of photolabelling and light-sh
 eet imaging\, we have traced the lineage contributions to the spinal cord 
 from head to tail of the zebrafish embryo. We suggest that NMps are a cons
 erved cell population that show vastly different rates of differentiation 
 and growth in a species-specific manner. I will present this data together
  with recent work exploring the dynamic regulatory networks that control N
 Mp competence and specification.\n\nBio:\nBen Steventon began his studies 
 in Developmental Biology as a PhD student with Roberto Mayor at UCL in 200
 4. After graduating in 2008\, he moved to KCL to work with Andrea Streit. 
 Subsequently he moved to the lab of Jean-Francois Nicolas and  Estelle Hi
 rsinger at the Institut Pasteur\, Paris. There\, he began to work with zeb
 rafish embryos to further the understanding of the tissue deformations tha
 t lead to the elongation of the embryonic body axis. To develop imaging an
 d analytical techniques to study this process at the cellular and molecula
 r levels\, he was awarded a Marie-Curie fellowship to work with Scott Fras
 er (University of California\, USA) and Alfonso Martinez-Arias (University
  of Cambridge). With his Wellcome Trust Sir Henry Dale fellowship\, he is 
 now applying these techniques to investigate how cell fate decisions are o
 rchestrated in space and time during axis patterning in zebrafish embryos.
 \n\n\n2016 onwards: Wellcome Trust/Royal Society Sir Henry Dale Fellow\nD
 epartment of Genetics\nUniversity of Cambridge\, UK\n \n2015-2016: Marie
  Curie International Incoming Fellow             \nAlfonso Martinez
 -Arias Lab\nUniversity of Cambridge\, UK\n \n2014-2015: Marie Curie Inter
 national Outgoing Fellow               \nScott Fraser Lab\nUnivers
 ity of Southern California\, USA\n \n2011-2014: Post-Doctoral Research As
 sistant                                     \nJean-Fran
 çois Nicolas and Estelle Hirsinger     \nInstitut Pasteur\, France\n
  \n2008-2011: Post-Doctoral Research Assistant                  
                    \nAndrea Streit Lab\nKings College London\, U
 K\n \n2008: JSPS Summer project fellow                       
                                                  
    \nTakehiro Kusakabe Lab\nHyogo University\, Japan\n \n2004-2008: PhD
  student                                            
                               \nRoberto Mayor Lab       
                                      \nUniversity Colle
 ge London\, UK    \n \n2001-2004: Bsc final year project         
                                                  
 \nRobert Kelsh Lab\nUniversity of Bath\, UK\n \n2003: Summer Project stud
 ent                                               
          \nRobert Kelsh\nUniversity of Bath\, UK
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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