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SUMMARY:Epithelial Bending for Organ Formation: Forces\, Molecular Signal
 s\, and Novel Ensemble Cell Behaviours
DTSTART:20171020T100000
DTEND:20171020T110000
DTSTAMP:20260510T235013Z
UID:c3de0d77af9a2dad054bd55b91a908d3fe391843b0d0d9cbe71b90ed
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jeremy Green\, King’s College London (UK)\nBIOENGINEER
 ING SEMINAR\n\nAbstract:\nEpithelial bending is a fundamental process of 
 developmental morphogenesis from the earliest stages of gastrulation to t
 he final stages of organogenesis. Classically\, epithelia bend by apical
  constriction in which apical actin contraction forces cells to become we
 dge-shaped. In principle\, this is not the only way a sheet of cells can b
 end itself. We have investigated invagination of epithelia to form mouse
  tooth buds\, hair follicles\, mammary ducts and salivary glands. A nove
 l family of epithelial bending mechanisms will be presented\, including s
 ome of the signals and forces that drive them\, and a broader set of pri
 nciples relevant to tissue morphogenesis as a whole.\n\nBio:\nJeremy Green
  is Professor of Developmental Biology at King’s College London. After a
  PhD at Imperial College London on yeast gene regulation\, he discovered d
 ose-dependency thresholds and the ratchet effect for morphogen cell-type s
 pecification. He was a Miller Fellow at UC Berkeley for two years before b
 ecoming a Principal Investigator at the Dana Farber Cancer Institute and H
 arvard Medical School Department of Genetics where he focused on Wnt signa
 lling and cell polarity. Recent interests include apicobasal and planar ce
 ll polarity in Xenopus and Turing patterning systems as well as physical m
 orphogenesis of mammalian tissue.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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