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SUMMARY:EESS talk on "How to assess human toxicokinetics of inhaled solven
 t ?"
DTSTART:20180515T121500
DTEND:20180515T131500
DTSTAMP:20260507T183145Z
UID:3ee1a7f595b0fc6df2e193fe032fd94616becbfe0e3253f597987a10
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Myriam Borgatta\, IST (Institut Universitaire romand de San
 té au Travail)\, CHUV\, Lausanne\nAbstract:\nGlycol ethers represent a gl
 obal market of several million tones and are present in a wide range of co
 nsumer products for domestic and professional use. Depending on the purpos
 e of use (e.g.\, cleaning\, painting\, cosmetics\, etc.) these products co
 ntain a wide variety of chemical components\, which can be easily inhaled.
  Millions of people\, including children\, are chronically exposed\, inten
 tionally or unintentionally\, to glycol ethers\, including propylene glyco
 l derivatives. Propylene Glycol monoMethyl Ether (PGME\, CAS no. 107-98-2)
  and Propylene Glycol monoButhyl Ether (PGBE\, CAS no 5131-66-8)\, are amo
 ng the five most used propylene glycol ether derivatives worldwide. Howeve
 r\, alone or in mixture\, the toxicological data of glycol ethers derived 
 from propylene glycol are deficient. For instance\, there are few or even 
 a complete lack of human data regarding hematotoxicity and the endocrine s
 ystem involved in reproduction for most glycol ethers\, especially from th
 e propylene glycol family. Moreover in Switzerland\, there are no occupati
 onal exposure limits for the propylene glycol PGBE and the OELs for glycol
  ether\, such as PGME\, is based on irritation and CNS effects. The worker
 s are thus exposed 8 hours a day to molecules with unknown effects. The ai
 m of the study is to determine the toxicokinetics of PGME and PGBE (indivi
 dually and in mixture) in healthy volunteers\, and the potential hematotox
 ic and reprotoxic effects from these molecules.\n\nShort biography:\nDr My
 riam Borgatta has a broad scientific background spanning from a PhD in eco
 toxicology\, MAS in general toxicology\, MSc in geosciences\, intensive ca
 re nursing. She is currently using her scientific and clinical skills in o
 ccupational and environmental toxicology research at Institute for work an
 d health (IST).
LOCATION:GR A3 32 https://plan.epfl.ch/?room==GR%20A3%2032
STATUS:CONFIRMED
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