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SUMMARY:Sorting Out Polarized Transport in Neurons
DTSTART:20171115T090000
DTEND:20171115T100000
DTSTAMP:20260510T235025Z
UID:6e14840e6e253a184179582efc9f277242a542e9ee4ce762309222d5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Lukas Kapitein\, Utrecht University (NL)\nBIOENGINEERING
  SEMINAR\n\nAbstract:\nProper positioning of organelles by cytoskeleton-ba
 sed motor proteins underlies cellular events such as signaling\, polarizat
 ion\, and growth. To explore how different motor proteins contribute to ne
 uronal transport and to study the site-specific roles of different organel
 les\, we have established optical control of intracellular transport by us
 ing light-sensitive heterodimerization to recruit specific cytoskeletal mo
 tor proteins (kinesin\, dynein or myosin) to selected cargoes. In addition
 \, to unravel how the specialized organization of the neuronal cytoskeleto
 n guides different motor proteins to either axons or dendrites\, we have d
 eveloped novel approaches for optical nanoscopy. One of these\, called mot
 or-PAINT\, uses nanometric tracking of motor proteins to super-resolve cyt
 oskeletal fibers and determine their polarity. This has revealed a key arc
 hitectural principle of the neuronal microtubule cytoskeleton that explain
 s how different motor proteins can selectively transport cargoes to either
  axons or dendrites.\n\nBio:\nLukas Kapitein studied Physics and Astronomy
  at the VU University in Amsterdam\, where he also received his PhD in Bio
 physics in 2007. His postdoctoral training in Neurobiology was at the Eras
 mus Medical Center\, funded by an NWO Vernieuwingsimpuls ALW-VENI grant an
 d an Erasmus MC Fellowship. As of 2011\, he works as an Assistant Professo
 r at Utrecht University. In 2013\, he received an ERC Starting Grant from 
 the European Research Council and a VIDI fellowship from the Netherlands O
 rganisation for Scientific Research.
LOCATION:BM 5202 https://plan.epfl.ch/?room==BM%205202
STATUS:CONFIRMED
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