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SUMMARY:Organoid Development by Design
DTSTART:20171204T121500
DTEND:20171204T131500
DTSTAMP:20260406T225907Z
UID:1e5184f257c2ba0ec73b6cf1f1c04e2be64668d25d3cef27ea661fc3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Matthias Lutolf\, Institute of Bioengineering\, EPFL\nAb
 stract :\nOver the past years\, organoids have stepped into the limelight 
 as unique in vitro models for studying organ development\, function and di
 sease\, owing to the previously unmatched fidelity with which they approxi
 mate real organs. Organoids form through poorly understood morphogenetic p
 rocesses in which initially homogeneous aggregates of stem cells spontaneo
 usly self-organize within three-dimensional extracellular matrices (ECM). 
 Yet\, the absence of any predefined patterning influences such as morphoge
 n gradients or mechanical cues results in an extensive heterogeneity. More
 over\, the current mismatch in shape\, size and lifespan between native or
 gans and their in vitro counterparts severely hinders their applicability.
  In this seminar\, I will discuss some of our ongoing efforts in developin
 g programmable organoids that we assemble by combining bioengineering appr
 oaches with insights from developmental biology. Specifically\, using inte
 stinal organoids (‘mini-guts’) as a model system\, I will\, for exampl
 e\, show how we can overcome the stochasticity in self-organization by con
 trolling cell fate decisions through localized changes in ECM mechanics. 
  I will also demonstrate how tissue shape per se confers robustness to org
 anoid development\, enabling for the first time to build macroscopic and o
 penly accessible intestinal epithelia having crypt-like domains at predete
 rmined positions. The convergence of bioengineering and cellular self-orga
 nization may be broadly applicable to attain more physiological organoid s
 izes\, shapes and function.\n\nBio:\nEducation/Training:\n   Dipl. Ing. 
 in Materials Science\, ETH Zurich (1999)\n   Ph.D. in Biomedical Enginee
 ring\, ETH Zurich (2003)\n   Postdoctoral\, Stanford University\, USA (2
 004-2006)\n\nPositions:\n   Tenure track Assistant Professor\, Institute
  of Bioengineering\, EPFL (2007 - 2013)\n   Associate Professor\, Instit
 ute of Bioengineering\, EPFL (2014 - present)\n   Director\, Institute o
 f Bioengineering\, EPFL (2014 - present)
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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