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PRODID:-//Memento EPFL//
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SUMMARY:“Role of sleep and oscillations in memory”
DTSTART:20120413T110000
DTEND:20120413T120000
DTSTAMP:20260506T084440Z
UID:1fc15bc130ae557c4bd73fee50a0751c1d8b152d46088885b798eeb0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Karim Benchenane\, PhD.\nUMR 7102 CNRS-Université Pierre et M
 arie Curie\, Paris\nMemory is a dynamical phenomenon\, from the moment of 
 encoding to retrieval. After encoding\, labile memories undergo consolidat
 ion\, that is\, they stabilize over time. The Buzsaki’s hypothesis (1989
 ) proposed that encoding occurs during awake hippocampal theta (5-10Hz) os
 cillations\, and consolidation during slow wave sleep\, involving reactiva
 tions that occur during hippocampal 200Hz oscillations called the sharp-wa
 ves-ripples complexes. We first showed that the two-stage memory consolida
 tion theory does not only rely on the sole hippocampus (as initially propo
 sed) but can also be extended to the hippocampal-prefrontal network\, and 
 proposed that dopamine could be a key actor of this process (Benchenane et
  al. Neuron 2010\, Benchenane et al. Curr Opinion Neurobiol 2011\, Peyrach
 e\, et al. Nat Neurosci 2009\; Battaglia et al.\, Trends Cogn Sci 2011). T
 he second main finding of my studies was to identify the causal role of ri
 pples on learning and memory consolidation (Girardeau*\, Benchenane* et al
 .\, Nat Neurosci 2009\, *co-authorship). We indeed showed that reactivatio
 ns during sleep are necessary to memory consolidation as subsequent perfor
 mance depends on ripple events. My current work focuses on the other poten
 tial roles of sleep in cognitive processes.\n
LOCATION:SV1717A
STATUS:CONFIRMED
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