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SUMMARY:Special LMNN Seminar // Molecular Imaging – Benefits of a Mass S
 pectrometry - Based Approach
DTSTART:20171213T110000
DTEND:20171213T120000
DTSTAMP:20260506T205207Z
UID:82edbfb3ff422a0070b9c97b736713b5a8b5867921e588626ac54de3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Martina Marchetti-Deschmann\, Institute of Chemical Technologi
 es and Analytics\, TU Wien\nMolecular mass spectrometry imaging (MSI) comb
 ines the chemical specificity and parallel detection possibility of mass s
 pectrometry (MS) with microscopic imaging capabilities. Molecular MSI is t
 herefore an emerging research field to detect intact molecules (analyte pr
 ofiling) and visualize their spatial distribution (analyte imaging).\nThe 
 utilization of “soft ionization” techniques as matrix-assisted laser d
 esorption/ionization (MALDI) allows the desorption and subsequent ionizati
 on of intact large\, surface-located (bio-) molecules to determine their e
 xact molecular weights by MS. Compared with many conventional MS approache
 s for cellular protein and peptide characterization MALDI MS based profili
 ng includes (a) the compatibility with crude mixtures\, (b) minimal sample
  clean up\, (c) no need for tagging or pre-selecting of the analyte\, (d) 
 high sensitivity\, (e) as a very important fact complementary information 
 to spectroscopic or immunological methods and (f) identification by tandem
  MS.\nThe presentation will introduce you to the field of MSI. It will sho
 w that experiments can be designed to selectively map peptides\, proteins\
 , lipids\, glycans or metabolites as well as administered pharmaceuticals.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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