BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Workshop in honor of Prof. Giorgio Margaritondo
DTSTART:20171207T090000
DTEND:20171207T123000
DTSTAMP:20260430T193447Z
UID:ea75b3eedad729b30e303bd3b13ea809ed4104b395928f26973529e7
CATEGORIES:Conferences - Seminars
DESCRIPTION:This workshop is organised to highlight some of the research f
 ields that were strongly influenced by by Prof. Giorgio Margaritondo in oc
 casion of his retirement.The event will be completed by  the Honorary Lec
 ture by prof. Margaritondo\, held on December 14th 17:15 - 20:00 RLC E1 
 240\n\nProgram :\n    9:00                Welcome – 
 Harald Brune IPHYS Director\n    9:05 – 9:50     Maya Kiskinova (
 Elettra-Sincrotrone\, Trieste)\n                           M
 icroscopy-imaging-scattering with Elettra Synchotron\n          
                   and FERMI FEL\n    9:50 – 10:35
    Antonio Cricenti (ISM-CNR\, Rome)\n                      
      Raman and Infrared SNOM nanospectroscopy\n            
                 for Tissue Imaging and Early Cancer Diagno
 stics\n    10:35 – 11:00  Coffee break\n    11:00 – 11:45  
 Yeu-Kuang Hwu (Academia Sinica\, Taiwan)\n                
             X-ray imaging of brain\n    11:45 – 12:30  
  Fauzia Albertin (IPHYS-EPFL)\n                            
 Tomography of ancient manuscripts \n \nMicroscopy-imaging-scattering with
  Elettra Synchrotron and FERMI FEL \nMaya Kiskinova\nElettra-Sincrotrone 
 Trieste\, Area Science Park\, 34149 Trieste\, Italy\nThe complementary cap
 abilities in terms of imaging\, spectroscopy\, spatial and time resolution
  of the instruments using synchrotron and free electron laser light have o
 pened unique opportunities to explore the properties of complex functional
  materials. Some recent achievements in imaging and micro-spot spectroscop
 y\, detecting emitted electrons or transmitted\, emitted and scattered pho
 tons will be illustrated by selected results obtained at Elettra laborator
 y. The examples will include (i) properties of nanostructured matter as a 
 function of composition\, dimensions and ambient\; (ii) evolution in morph
 ology and chemical state of key constituents in electrochemical devices du
 ring fabrication or operating conditions\; (iii) tracking ultrafast dynami
 cs triggered by external stimuli with access to elemental and/or magnetic 
 and electronic structure of the specimen.\n\nRaman and Infrared SNOM nanos
 pectroscopy for Tissue Imaging and Early Cancer Diagnostics \nA. Cricenti\
 nIstituto di Struttura della Materia (ISM-CNR)\, via del Fosso del Cavalie
 re 100\, Rome\, 00133\, Italy\,\ne-mail: antonio.cricenti@ism.cnr.it\nCarc
 inomas are complex biochemical systems and in the past their diagnosis was
  based on morphological differences between malignant cells and their beni
 gn counterpart. Recently the paradigm has changed and great interest is fo
 cused now on the biochemical profile of tumours in view of the availabilit
 y of new drugs that specifically target neoplastic cells. This new paradig
 m requires biochemical analysis of each tumour in order to establish the c
 orrect personalized oncological “target therapy”. Understanding the me
 chanism of molecular alterations of a specific tumour is a critical issue 
 to prognosticate its behaviour and to predict the response to personalized
  therapy.\nRaman spectroscopy (RS) is a non-invasive optical label-free to
 ol increasingly used to get molecular fingerprints of biological tissues. 
 It is able to provide bioanalytical information on any molecule with high 
 specificity. Technological advances over the last decade have created a ne
 w and faster Raman imaging microscope instrument\, providing morphological
  tissue investigation of large areas\, coupled with point-by-point spectra
 l analysis of biochemical composition. This option is important not only f
 or discrimination between healthy and pathological tissues but especially 
 for pre-cancerous tissue state earlier detection and understanding. Raman 
 mapping of biological tissues has shown that the microscope can operate at
  a few micron resolution\, in order to distinguish between healthy and mal
 ignant tissues [1].\nThe potential of IR spectroscopy to characterise canc
 erous tissues has long been recognised and studies of various cancers by m
 any groups have established that regions of malignant tissue can be easily
  identified on the basis of its IR spectrum. Early diagnosis of cancer req
 uires an instrument providing specific chemical images at sub-cellular lev
 el and the development of diagnostic imaging. A SNOM meets these requireme
 nts provided that it can be coupled with an appropriate infrared light sou
 rce\, that can be based on Free Electron Laser\, femtosecond laser or quan
 tum cascade laser [2].\nWe present Raman and Infrared Scanning Near-field 
 Optical Microscopy (SNOM) in their spectroscopic mode\, that is related to
  the local chemical composition and\, thus\, to the biological properties 
 of the sample\, for tissue imaging and early cancer diagnostics. Applicati
 ons in the case of Oesophagus [3] and Cervical Cancer [4] as well as in th
 e progression of Amyotrophic Lateral Sclerosis (ALS) will be presented.\n[
 1] Çulha M\, Bioanalysis\, 7\, 2813 (2015)\n[2] Cricenti A\, Luce M\, Tol
 k NH\, Margaritondo G\; Nanosci. Nanotechnol. Lett.\; 3 (2011) 913\;\n[3] 
 Smith AD\, Siggel-King MRF\, Holder GM\, Cricenti A\, Luce M\, Harrison P\
 , Martin DS\, Surman M\, Craig T\, Barrett SD\, Wolski A\, Dunning DJ\, Th
 ompson NR\, Saveliev Y\, Pritchard DM\, Varro A\, Chattopadhyay S\, Weight
 man P\; Applied Physics Letters\; 102 (2013) 053701.\n[4] Halliwell Diane 
 E\, Morais Camilo LM\, Lima Kássio MG\, Trevisan Julio\, Siggel-King Mich
 ele RF\, Craig Tim\, Ingham James\, Martin David S\, Heys Kelly A\, Kyrgio
 u Maria\, Mitra Anita\, Paraskevaidis Evangelos\, Theophilou Georgios\, Ma
 rtin-Hirsch Pierre L\, Cricenti Antonio\, Luce Marco\, Weightman Peter\, M
 artin Francis L\; Nature Scientific Reports\; 6 (2016) 29494.\n \nX-ray i
 maging of brain \nYeu-Kuang Hwu\, Ann-Shyn Chiang and Giorgio Margaritondo
 \nInstitute of Physics\, Academia Sinica\, Taipei\, Taiwan\nComprehensive 
 mapping of neural networks in the brain is a formidable but very exciting 
 challenge. The complexity of the complete network is beyond the current te
 chnology to describe\, analyze and understand.\nIt is now a consensus that
  the first step towards understanding brain functions is to construct a ba
 sic map – a connectome – showing the neural network at the level of si
 ngle neurons and connections. As one of the six “high priority challenge
 s” in the US BRAIN Initiative: “Maps at multiple scales: Generate circ
 uit diagrams that vary in resolution from synapses to the whole brain”\,
  we believe our approach will transform this vision onto reality.\nThe key
  element in our technology arsenal is the phase contrast micro- and nano-t
 omography. Using the same x-ray photons with the nanotomography instrument
 \, the fine details of the same specimens can be imaged in 3D with <20 nm 
 resolution. This allows us to examine the smallest network features\, such
  as dendrites and dendritic splines\, within specific regions\, since they
  can be important for the whole brain network structure.\n\nTomography of 
 ancient manuscripts \nFauzia Albertin \nIPHYS EPFL\nEuropean manuscripts 
 collections are part of our irreplaceable patrimony and contain an incredi
 ble wealth of precious documents and historical information. However\, ope
 n access for the general public and scholars alike is often restricted due
  to preservation concerns. Massive digitization programs started in recent
  years are offering only a partial solution: digitization remains a slow a
 nd expensive process and the imaging of fragile or un-opened documents a f
 ormidable challenge.\nThe new x-ray tomography technique developed at EPFL
  can tackle these problems in a non-invasive way\, making digitization of 
 entire manuscripts feasible without opening them or turning pages\, thus m
 inimizing the handling and potentially accelerating the overall digitizati
 on procedure. Thanks to the high penetration of x-rays\, we can acquire 3D
  tomographic images of multi-page manuscripts without opening them. The x-
 ray contrast necessary for the readability is obtained by exploiting the c
 hemical composition and the high-absorbing power of the Iron Gall inks –
  largely used for European handwritten documents.\nI will present the deve
 lopment of this technology\, from the chemical investigations of the ancie
 nt inks to the tomography an unopened Venetian testament and of an 18th ce
 ntury\, 200-page\, handwritten book.
LOCATION:INJ 218 https://plan.epfl.ch/?request_locale=en&room=INJ%2B218&di
 m_floor=2&lang=en&dim_lang=en&baselayer_ref=grp_backgrounds&tree_groups=ce
 ntres_nevralgiques%2Cacces%2Cmobilite_reduite%2Censeignement%2Ccommer
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR