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SUMMARY:Translating the Precision Electrophile Signaling Code
DTSTART:20171122T161500
DTEND:20171122T171500
DTSTAMP:20260512T015115Z
UID:64e254fbdb16c71d042f19f742d0e2adf11432d757679f37b92e2e46
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Yimon Aye\, Cornell University\nPrecisely timed and spat
 ially regulated electrophilic chemical signals are the essence of biochemi
 cal redox signaling. However\, defining the precise biological impacts of 
 localized signals that engage with specific protein targets under physiolo
 gic conditions has proven to be highly challenging. This talk presents a u
 nique set of proximity-directed chemical tools that enables interrogation 
 into functional consequences of specific redox events through precision el
 ectrophile targeting in living systems. With this in vivo-validated redox-
 targeting toolset\, we identify bona fide “first responders” that inte
 ract with native signaling electrophiles under electrophile-limited (true
  kcat/Km) conditions. Our data illuminate these first responders as novel
  signaling nodes\, interchanging electrophile and conventional signaling c
 odes such as phosphate and ubiquitin for decision making at organismal lev
 el. Our unique chemical biology toolset sets the stage for ruling in gain-
 of-function (or dominant loss-of-function) electrophilic modifications and
  relating them to phenotype in an unbiased experiment that is not hampered
  by functional redundancy. With the growing importance of covalent drugs i
 n the treatment of various human disorders\, our new ability to surgically
  examine precision covalent electrophile signaling mechanisms opens new av
 enues toward targeted therapeutics and novel target discovery.
LOCATION:BCH 5310 https://plan.epfl.ch/?room==BCH%205310
STATUS:CONFIRMED
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