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SUMMARY:Quantitative Analysis of in vivo Energy Metabolism
DTSTART:20171127T103000
DTSTAMP:20261001T033937Z
UID:73a118ba591f95c1b25766eb7ec2797104f84f031f1565dc4b60cd67
CATEGORIES:Conferences - Seminars
DESCRIPTION:Sheng (Tony) Hui\, Ph.D.\, Princeton University\, Princeton\, 
 NJ (USA)\nBIOENGINEERING SEMINAR\n\nAbstract:\nThe primary biochemical act
 ivity of an adult mammal is energy metabolism\, the constant burning of di
 etary carbons into CO2. Underlying this simple overall chemical reaction i
 s diverse energy metabolism in individual tissues. Tissues take their fuel
 s from the bloodstream\, which carries not only nutrients directly from di
 gestion but also metabolite intermediates released by tissues themselves. 
 What are the important nutrients in the blood circulation? How are these n
 utrients selected by tissues for energy? And by which tissues are they pro
 duced? To answer these important questions\, I first systematically quanti
 fy the turnover fluxes of the circulatory metabolites (Fcirc) in mice. The
  result reveals a short list of circulatory metabolites with significant t
 urnover fluxes: only 15 metabolites have a Fcirc greater than 10% of the g
 lucose Fcirc. Strikingly\, the Fcirc of lactate exceeds those of glucose a
 nd other metabolites\, and 13C-lactate extensively labels TCA cycle interm
 ediates in all tissues. Quantitative analysis reveals that with the except
 ion of the brain and (only in the fed state) muscle\, glucose contributes 
 to tissue TCA metabolism primarily indirectly via circulating lactate. Thi
 s points to a new structure of glucose metabolism: glycolysis and the TCA 
 cycle are uncoupled at the level of lactate. Next\, I am working through t
 he list of nutrients with high Fcirc to determine their contributions to t
 issue TCA metabolism\, and quantifying tissue sources and sinks of importa
 nt circulatory nutrients by an innovative approach of combining isotopic t
 racer infusion and arteriovenous difference measurement. These results wil
 l be integrated into a whole-body flux model of energy metabolism.\n\nBio:
 \nExperience:\n    Jan 2015 – Present\n    Princeton University\
 , Princeton\, NJ (USA)\n    Postdoctoral Research Fellow\n\n    Ju
 l 2014 – Dec 2014\n    University of California\, San Diego\n   
  Postdoctoral Research Associate\n\nEducation:\n    2007 – 2014\n 
    University of California\, San Diego\n    Ph.D. in Biophysics\n\
 n    2006 – 2007\n    Rutgers\, The State University of New Jers
 ey-Newark\n    Computational Biology\n\n    2003 – 2005\n   
  Hong Kong Baptist University\n    Master's Degree in Physics\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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