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SUMMARY:BMI SPECIAL SEMINAR // Neural circuitry for context-dependent beha
 vior and learning
DTSTART:20180111T150000
DTEND:20180111T160000
DTSTAMP:20260510T053547Z
UID:69c44c8d654daaf56d09a810866610fcd00c9f2e5014b006fb8d4b10
CATEGORIES:Conferences - Seminars
DESCRIPTION:Kishore Kuchibhotla\, Dpt.of Psychological & Brain Sciences\, 
 Johns Hopkins University\, Baltimore\, USA\nAbstract: Sensory stimuli conv
 ey critical information about various types of opportunities and threats\,
  including access to nourishment\, the presence of predators\, or the need
 s of infants. The same sensory stimulus\, however\, can have different int
 erpretations based on learned associations and the contexts within which i
 t is presented. How does the brain enable such interpretation of sensory c
 ues based on behavioral context? A major challenge in neural systems is to
  provide logic to complex neural dynamics. In this talk\, I will show how 
 parallel processing of cholinergic modulation by diverse cortical interneu
 rons enables the same sensory stimuli to trigger different behaviors depen
 ding on context. Surprisingly\, excitatory synaptic inputs themselves are 
 only modestly affected by context. Instead\, during active engagement\, ch
 olinergic input co-activates multiple interneurons thereby adjusting inhib
 itory synaptic inputs and consequently modulating neuronal output. A netwo
 rk model captured these dynamics across neuronal subtypes only when neurom
 odulation coincidently drove inhibitory and disinhibitory circuit elements
 \, ruling out either as sole computational responses to cholinergic modula
 tion. I will finally present preliminary data and modeling on how context 
 shapes the learning process itself.\n\nShort Biography: Kishore is an Assi
 stant Professor at Johns Hopkins University in the Departments of Psycholo
 gical and Brain Sciences and Neuroscience (circuits.jhu.edu). He earned ba
 chelor degrees in Physics and Brain/Cognitive Science at MIT. He went on t
 o earn his PhD in Biophysics at Harvard University under the mentorship of
  Drs. Brian Bacskai and Bradley Hyman. Kishore completed his postdoctoral 
 work at NYU with Dr. Robert Froemke.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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