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SUMMARY:BMI SEMINAR // Extracellular matrix and neuroplasticity in health 
 and disease
DTSTART:20180131T121500
DTEND:20180131T131500
DTSTAMP:20261001T173706Z
UID:bf884aeb37ddc283d1c4e004d8430ac1811490007db9a7ff529e72cf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Alexander Dityatev\, Molecular Neuroplasticity Group\, German 
 Center for Neurodegenerative Disorders\, Magdeburg\, Germany  \nNeural ex
 tracellular matrix (ECM) molecules derived from neurons and glial cells ac
 cumulate in the extracellular space and regulate synaptic plasticity throu
 gh modulation of perisomatic GABAergic inhibition\, intrinsic dendritic an
 d axonal excitability\, lateral diffusion of synaptic molecules\, integrin
  signaling\, as well as activities of L-type Ca2+ channels\, NMDA receptor
 s\, and small GTPases (Dityatev et al.\, Nat Rev Neurosci\, 2010). Genetic
  or enzymatic targeting of ECM molecules proved to bi-directionally modula
 te synaptic plasticity and acquisition/recall of memories\, depending on e
 xperimental conditions\, and to promote cognitive flexibility and extincti
 on of fear and drug memories (Senkov et al.\, Progr Brain Res\, 2014). Upr
 egulation of ECM expression is associated with aging and dementia\, while 
 epileptic seizures and schizophrenia may result in attenuation of ECM. Thu
 s\, the neural ECM appeared as a key component of synaptic plasticity\, le
 arning and memory\, and may be linked to cognitive dysfunctions in major b
 rain disorders.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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